Primary Information | |
---|---|
BoMiProt ID | Bomi9297 |
Protein Name | Solute carrier family 15 member 4/Peptide/histidine transporter 1 |
Organism | Bos taurus |
Uniprot ID | A6QQL0 |
Milk Fraction | Whey |
Ref Sequence ID | NP_001095397.2 |
Aminoacid Length | 566 |
Molecular Weight | 61380 |
FASTA Sequence | Download |
Gene Name | SLC15A4/PHT1 |
Gene ID | 510499 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | transmembrane protein consisting of 12 membrane-spanning regions and transports specific amino acids, oligopeptides, and carnosine coupled proton.responsible for transporting lipids, amino acids, sugars, neurotransmitters, and drugs across the biological membranes.essential in Toll-like receptor (TLR) stimulation and NOD2-NF-κB pathway activation in dendritic cells. |
Biochemical Properties | 12 membrane-spanning regions and transports certain types of amino acids, particularly histidine, and oligopeptides such as nucleotide oligomerization domain-1 (NOD1) ligand, L-Ala-γ-D-Glu-meso-diaminopimelic Acid (tri-DAP), and carnosine, together with a proton.Its transporter activity is pH-dependent maximized in the acidic lysosomal environment. |
PTMs | Phosphorylation on Ser |
Linking IDs | Bomi9297 |
Bibliography | 1.Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N. The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production. Immunity. 2014 Sep 18;41(3):375-388. doi: 10.1016/j.immuni.2014.08.011. PMID: 25238095. 2.Saikrithi P, Balasubramanian CP, Otta SK, Tomy S. Expression dynamics of solute carrier family 15 member 4 (SLC15A4) and its potential regulatory role in ovarian development of the Indian white shrimp, Penaeus indicus. Mol Biol Rep. 2020 May;47(5):3797-3805. doi: 10.1007/s11033-020-05471-x. Epub 2020 May 3. PMID: 32363413. |
Protein Function | transmembrane protein consisting of 12 membrane-spanning regions and transports specific amino acids, oligopeptides, and carnosine coupled proton.responsible for transporting lipids, amino acids, sugars, neurotransmitters, and drugs across the biological membranes.essential in Toll-like receptor (TLR) stimulation and NOD2-NF-κB pathway activation in dendritic cells. |
Biochemical Properties | 12 membrane-spanning regions and transports certain types of amino acids, particularly histidine, and oligopeptides such as nucleotide oligomerization domain-1 (NOD1) ligand, L-Ala-γ-D-Glu-meso-diaminopimelic Acid (tri-DAP), and carnosine, together with a proton.Its transporter activity is pH-dependent maximized in the acidic lysosomal environment. |
PTMs | Phosphorylation on Ser |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|A6QQL0|S15A4_BOVIN Solute carrier family 15 member 4 OS=Bos taurus OX=9913 GN=SLC15A4 PE=2 SV=2 MEGAGDERAPLLGARRTAFAGRRAACAAVLLTELLERAAFYGVTANLVLFLNGTAFGWEG AEASQALLLFMGLTYLVSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPATRSA LCGAPGPTNVRNCSAPPCTDTPTRYCAPAVLSALALVGLGVGAVKANITPFGADQVKDRG PEATRRFFNWFYWSINLGAIVSLGGIAYIQQNVSFVTGYAIPAVCIGVAFVVFLCGQTFF ITKPPDGSAFTDMFRILVYSCRPQKRIREHSPSGEGIGVFQQSSKHSLFDS*291CKMSRGGPF PEDKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLKIPEISSITTNPHTFPAA WLTMFDAVLILLLIPLKDKLVDPILKRNGLLPSSLKRIAVGMFFVMCSAFAAGILESKRL DLVKEKTINQTIGNVVYYAADLPIWWQVPQYVLIGVSEIFASIAGLEFAYSAAPKSMQSA IMGLFFFFSGVGSFVGSGLLALVSLKAIGWMSSHTDFGNINGCYLNYYFFLLAAIQGATL LLFLIVSVKYDRQRSRANGTPASRRT |
Predicted Disorder Regions | 1-18, 559-566 |
DisProt Annotation | |
TM Helix Prediction | 11TMHs; (38-60), (67-85), (94-112), (187-209), (213-235), (310-328), (358-376), (397-415), (448-470), (483-505), (524-546) |
Linking IDs | |
Bibliography | 1.Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N. The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production. Immunity. 2014 Sep 18;41(3):375-388. doi: 10.1016/j.immuni.2014.08.011. PMID: 25238095. 2.Saikrithi P, Balasubramanian CP, Otta SK, Tomy S. Expression dynamics of solute carrier family 15 member 4 (SLC15A4) and its potential regulatory role in ovarian development of the Indian white shrimp, Penaeus indicus. Mol Biol Rep. 2020 May;47(5):3797-3805. doi: 10.1007/s11033-020-05471-x. Epub 2020 May 3. PMID: 32363413. |