Primary Information |
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| BoMiProt ID | Bomi9280 |
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| Protein Name | Sodium/potassium/calcium exchanger 1(Retinal rod Na-Ca+K exchanger) or Solute carrier family 24 member 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q28139 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_777080.1 |
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| Aminoacid Length | 1216 |
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| Molecular Weight | 131614 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC24A1/NCKX1 |
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| Gene ID | 282474 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | component of the visual transduction cascade.Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.controlling the calcium concentration of outer segments during light and darkness. |
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| Biochemical Properties | The large, N-terminal hydrophilic domain is extracellular and immediately follows the N-terminal signal sequence, distinguishing this class of cationic exchangers from others that do not contain this large hydrophilic loop. |
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| PTMs | Glycosylation on Asn and Phosphorylation on Ser and Thr |
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| Linking IDs | Bomi9280 |
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| Bibliography | McKiernan CJ, Friedlander M. The retinal rod Na(+)/Ca(2+),K(+) exchanger contains a noncleaved signal sequence required for translocation of the N terminus. J Biol Chem. 1999 Dec 31;274(53):38177-82. doi: 10.1074/jbc.274.53.38177. PMID: 10608890. |
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| Protein Function | component of the visual transduction cascade.Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.controlling the calcium concentration of outer segments during light and darkness. |
|---|
| Biochemical Properties | The large, N-terminal hydrophilic domain is extracellular and immediately follows the N-terminal signal sequence, distinguishing this class of cationic exchangers from others that do not contain this large hydrophilic loop. |
|---|
| PTMs | Glycosylation on Asn and Phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q28139|NCKX1_BOVIN Sodium/potassium/calcium exchanger 1 OS=Bos taurus OX=9913 GN=SLC24A1 PE=1 SV=2
MGKLIRMGAQERRSLWPKRLHWSRPLFLLGMLIIGSTYQYLTSPQGLPTLWAAVSSQHPV
KVASRDLSNKEMMMVSSETSKSSSEMEVEAWAPEATAGRDGTPPGIARKNTPSTPRGTAS
ITPAIPNNYSPTPTGTGKVKEDTSATPSGVLNHYTQSRPMVNSYTRLTARGEVKSSRPTQ
SRGKEEKYSPSPLGRMVNSYAPSTLMTMPRSHGITPRTTVKDREIMATKKMLATNPSKRL
VEKTTPTPLKGITDNTPTFLLSDLETDTLTSPRNVVEKKTLTTPRRVDSN*290SSTNHQGLVG
KNN*303LTTPQGMVLEHTAAVSEGQVTISTMTRSSPTETKASTDAWKVRNPLPRTSAPIIRIS
SATFRGLLKNPSKAPSTPAAPRVRANPTIQVRHCLVVEPAPVAPTAPSPSWTTAVIPGIP
SPSGQPDLYPKAEYPRDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITD
KLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALF
SREILNLTWWPLFRDITFYIFDLMMLILFFLDSLIAWWESVLLLLAYAFYVFTMKWNQQL
ELWVKEQLNKRPVAKVMALGDLSKPGDGTVVVDEQQDNKKLKLSSMLTRGSS*652SASLHNST
IRSTIYQLMLHSLDPLGEARPSKDKEEETLIPEAKATPQAKAESKPEEEPAKLPEVT*717VTP
APAPDVKGDQEEDPGSQGVGAEAENTGERTGGEAEAPAEGENGERSGGDAALGGESEGKA
ENESEGDIPAERRGDDEDEGEIQAEGGEVKGDEDEGEIQAGEGGEVEGDEDEGEIQAGEG
GEVEGDEDEGEIQAGEAGEVEGDEDEGEIQAGEGGEVEGDEDEGEIQAGEAGEVEGDEDE
GEIQAGEGGEVKGDEGEIQAGEAGEVEGEDGEVEGGEDEGEIQAGEGGEGETGEQELNAE
IQGEAKDDEEGVDGEGGGDGGDSEDEEEEDEEEEDEEEEEEEEEEEEEENEQPLSLEWPE
TRRKQAIYLFLLPIVFPLWLTVPDVRRLEAKKFFVITFLGSILWIAMFSYLMVWWAHQVG
ETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWM
LFSLINGLQPVAVSSNGLFCAIVLLFLMLLFVISSIALCKWRMNKILGFTMFLLYFVFLI
ISVMLEDRIISCPVSV |
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| Predicted Disorder Regions | 3 disordered segments; (78-205), (256-376) , (715-1019) |
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| DisProt Annotation | |
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| TM Helix Prediction | 11TMHs; (20-42), (448-466), (518-540), (549-571), (574-592), (1025-1043), (1056-1074), ( 1089-1111), (1124-1142), (1157-1179), & (1186-1204) |
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| Linking IDs | |
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| Bibliography | McKiernan CJ, Friedlander M. The retinal rod Na(+)/Ca(2+),K(+) exchanger contains a noncleaved signal sequence required for translocation of the N terminus. J Biol Chem. 1999 Dec 31;274(53):38177-82. doi: 10.1074/jbc.274.53.38177. PMID: 10608890. |
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