Primary Information | |
---|---|
BoMiProt ID | Bomi8823 |
Protein Name | RING finger protein 207 |
Organism | Bos taurus |
Uniprot ID | A0JNG4 |
Milk Fraction | Whey |
Ref Sequence ID | NP_001071525.1 |
Aminoacid Length | 556 |
Molecular Weight | 61668 |
FASTA Sequence | Download |
Gene Name | RNF207 |
Gene ID | 616057 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | novel RING-finger protein 207 (RNF207), which is specifically expressed in the heart, plays a role in cardiac energy metabolism.Imp for cellular concentration of adenosine triphosphate (ATP) and mitochondrial function.RNF207 interacts with the voltage-dependent anion channel (VDAC), which is considered to be a key regulator of mitochondria function. |
Biochemical Properties | (RING)-finger domain contains eight metal-binding residues that coordinate two zinc atoms forinc motifs are called as B boxes.Region containing B-boxes and the coiled-coil is likely to be responsible for the interaction with substrates.RING-finger domain, which is known to be required for the activities of E3 ubiquitin ligases. |
Linking IDs | Bomi8823 |
Bibliography | Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S. The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol. 2016 Nov;100:43-53. doi: 10.1016/j.yjmcc.2016.09.013. Epub 2016 Sep 25. PMID: 27677939. |
Protein Function | novel RING-finger protein 207 (RNF207), which is specifically expressed in the heart, plays a role in cardiac energy metabolism.Imp for cellular concentration of adenosine triphosphate (ATP) and mitochondrial function.RNF207 interacts with the voltage-dependent anion channel (VDAC), which is considered to be a key regulator of mitochondria function. |
Biochemical Properties | (RING)-finger domain contains eight metal-binding residues that coordinate two zinc atoms forinc motifs are called as B boxes.Region containing B-boxes and the coiled-coil is likely to be responsible for the interaction with substrates.RING-finger domain, which is known to be required for the activities of E3 ubiquitin ligases. |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
Predicted Disorder Regions | 332-367, 523-556 |
DisProt Annotation | |
TM Helix Prediction | no TM helices |
Linking IDs | |
Bibliography | Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S. The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol. 2016 Nov;100:43-53. doi: 10.1016/j.yjmcc.2016.09.013. Epub 2016 Sep 25. PMID: 27677939. |