Primary Information | |
---|---|
BoMiProt ID | Bomi8432 |
Protein Name | Protein THEMIS/Thymocyte-expressed molecule involved in selection |
Organism | Bos taurus |
Uniprot ID | A5D789 |
Milk Fraction | Whey |
Ref Sequence ID | NP_001091585.1 |
Aminoacid Length | 641 |
Molecular Weight | 73132 |
FASTA Sequence | Download |
Gene Name | THEMIS |
Gene ID | 540554 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | Plays a critical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in signaling downstream of the T cell antigen receptor (TCR) |
Biochemical Properties | THEMIS, a recently identified T-lineage-restricted protein, is the founding member of a large metazoan protein family. |
PTMs | Phosphorylation at Ser |
Significance of PTMs | Phosphorylated on Tyr residues quickly after TCR stimulation |
Additional Comments | THEMIS is constitutively bound to the tyrosine phosphatases SHP1 or SHP2, provides a mechanism for THEMIS action. |
Linking IDs | Bomi8432 |
Bibliography | 1.Choi S, Cornall R, Lesourne R, Love PE. THEMIS: Two Models, Different Thresholds. Trends Immunol. 2017 Sep;38(9):622-632. doi: 10.1016/j.it.2017.06.006. Epub 2017 Jul 8. PMID: 28697966; PMCID: PMC5788012. 2.Gascoigne NR, Acuto O. THEMIS: a critical TCR signal regulator for ligand discrimination. Curr Opin Immunol. 2015 Apr;33:86-92. doi: 10.1016/j.coi.2015.01.020. Epub 2015 Feb 18. PMID: 25700024. |
Protein Function | Plays a critical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in signaling downstream of the T cell antigen receptor (TCR) |
Biochemical Properties | THEMIS, a recently identified T-lineage-restricted protein, is the founding member of a large metazoan protein family. |
PTMs | Phosphorylation at Ser |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|A5D789|THMS1_BOVIN Protein THEMIS OS=Bos taurus OX=9913 GN=THEMIS PE=2 SV=1 MALSLEEFIHSLDLRTLPRVLEIQSGFYFEGSIYEMFGNECCLSTGEVIKITDLKIKKIM AEICEHVEGCVSPQSFELPMNFPGLFKIVADTTPYLTMEEITKANHIRPSRPNHPCFYHQ KDIKLENLIIKKGERIMLNSVEEINGEIMVNCSVLRNHQNHSFTLPLSQEGEFYECEDEH IYTLKEIIQWKIPKNRTRTVILTGFSAKWDSTNPFPRGFYGAVILKPVYEIQAVMKFRKD IVRILPSLDVEVKDITDSYDANWFLQVLSTQDLYEMANKQFPIVAEVIEAPQGNQLPISI LQPGKTIVIHKKCQASKILASEIRSNSSKRHFLIPTSYKGKFKRRPREFPTAYDLEIAKS EKEPLHVVATKAFHSPFEELSSVSVGDEFLVHHSQTTEVLCEGIKKVMDGLACEKILKNS REVALLPLYMDGGFVEVIHDKKLYQISELCAQFRLPFNVKVSVRDLFIEKDILAAIPGLQ LEESITNSYLLISDLANPKKCWEIPVGRVNMTVQLVNNFSGDTGSFLVSTLVEEITEEQY YLIRRYEKSFLHPPPRPPKHPSVEKIELTPLSLAKQKTVNLPKS*584PKSVHVDRSKKLYSNQ AGLDSKVPAGCQNDLADLEKEKRKTEATAVTEIFKTEEHKK |
Predicted Disorder Regions | 576-641 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
Significance of PTMs | Phosphorylated on Tyr residues quickly after TCR stimulation |
Additional Comments | THEMIS is constitutively bound to the tyrosine phosphatases SHP1 or SHP2, provides a mechanism for THEMIS action. |
Linking IDs | |
Bibliography | 1.Choi S, Cornall R, Lesourne R, Love PE. THEMIS: Two Models, Different Thresholds. Trends Immunol. 2017 Sep;38(9):622-632. doi: 10.1016/j.it.2017.06.006. Epub 2017 Jul 8. PMID: 28697966; PMCID: PMC5788012. 2.Gascoigne NR, Acuto O. THEMIS: a critical TCR signal regulator for ligand discrimination. Curr Opin Immunol. 2015 Apr;33:86-92. doi: 10.1016/j.coi.2015.01.020. Epub 2015 Feb 18. PMID: 25700024. |