Primary Information | |
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BoMiProt ID | Bomi8422 |
Protein Name | Protein SMG8/Protein smg-8 homolog |
Organism | Bos taurus |
Uniprot ID | A1A4J7 |
Milk Fraction | Whey |
Ref Sequence ID | NP_001073755.1 |
Aminoacid Length | 999 |
Molecular Weight | 110135 |
FASTA Sequence | Download |
Gene Name | SMG8 |
Gene ID | 522040 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | take part in Nonsense-mediated mRNA decay (NMD) of mRNAs containing premature stop codons. |
Biochemical Properties | SMG8 has a C-terminal kinase inhibitory domain (KID), which covers the catalytic pocket and inhibits the kinase activity of SMG1. SMG8 and SMG9 form a pseudo symmetric dimer and the interaction is mediated by extensive hydrophobic contacts.Residues L274, L279 and H297 of SMG9 Switch II bind to residues F219, I221, D224 and I311 of SMG8. |
PTMs | Methylation and phosphorylation on Ser |
Linking IDs | Bomi8422 |
Bibliography | Zhu L, Li L, Qi Y, Yu Z, Xu Y. Cryo-EM structure of SMG1-SMG8-SMG9 complex. Cell Res. 2019 Dec;29(12):1027-1034. doi: 10.1038/s41422-019-0255-3. Epub 2019 Nov 15. PMID: 31729466; PMCID: PMC6951342. |
Protein Function | take part in Nonsense-mediated mRNA decay (NMD) of mRNAs containing premature stop codons. |
Biochemical Properties | SMG8 has a C-terminal kinase inhibitory domain (KID), which covers the catalytic pocket and inhibits the kinase activity of SMG1. SMG8 and SMG9 form a pseudo symmetric dimer and the interaction is mediated by extensive hydrophobic contacts.Residues L274, L279 and H297 of SMG9 Switch II bind to residues F219, I221, D224 and I311 of SMG8. |
PTMs | Methylation and phosphorylation on Ser |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|A1A4J7|SMG8_BOVIN Nonsense-mediated mRNA decay factor SMG8 OS=Bos taurus OX=9913 GN=SMG8 PE=2 SV=2 MAGPVSLRELLMGASAWTSSESPEGSPTEGGGSAAGGPEPPWREDEICVVGIFGKTALRL NSEKFSLVNTVCDRQVFPLFRHQDPGDSGAGIRTEAGAVGEAGGAGDPGAGAGAGAGAGA GDPVRGGVTAAEGNRTEPGSQDYSLLQAYYNQESKVLYLLLTSICDNSQLLRACRALQSG EAGGGLSLPHAEAHEFWKHQEKVQCLSLLYLFSVCHILLLVHPTCSFDITYDRVFRALDG LRQKVLPLLKTAIKDCPVGKDWKLNCRPCPPRLLFLFQLNGALKVEPPRNQDPAHPDKPK KHSPKRRLQHALEDQIYRIFRKSRVLTNQSINCLFTVPANQAFVYIVPGSQEEDPVGMLL DQLKSHCTVKDPESLLVPAPLSGSRRYQVMRQHSRQQLSFHTDTSSSSSSGQLVDFTLRE FLWQHVELVLSKKGFDDSVGRNPQPSHFELPTYQKWISAASKLYEVAIDGKEEDPAS*477PTG ELTSKILSSIKVLEGFLDIDTKFSENRCQKALPMAHSAYQSNLPHNYTMTVHKNQLAQAL RVYSQHARGPAFHKYAMQLHEDCYKFWSNGHQLCEERSLTDQHCVHKFHSLPKSGEKPEA DRNPPVLYHNSRARSTGACNCGRKQAPRDDPFDIKAANYDFYQLLEEKCCGKLDHINFPV FEPSTPDPAPAKNESS*676PAPPDADADKLKEKEPQTQGESTSLSLALSLGQSTDSLGTYPAD PQAGGDNPEVHGQGEVKTEKRPNLVDRQAS*750TVEYLPGMLHSNCPKGLLPKFSSWSLVKLG PAKSYNFHTGLDQQGFIPGTNYLMPWDIVIRTRAEDEGDLDTNSWPAPNKAVPGKRSAVV MGRGRRRDDIARAFVGFEYEDSRGRRFMCSGPDKVMKVMGSGPKESALKALNSDMPLYIL SSS*903QGRGLKPHYAQLMRLFVVVPDAPLQIILTPQVRPGPPPCPVFYPEKQEITLPPDGLW VLRFPYAYVTERGPCFPPKENVQLMSYKVLRGVLKAVTQ |
Predicted Disorder Regions | 18-42, 87-95, 114-138, 290-306, 675-735, 837-843 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
Linking IDs | |
Bibliography | Zhu L, Li L, Qi Y, Yu Z, Xu Y. Cryo-EM structure of SMG1-SMG8-SMG9 complex. Cell Res. 2019 Dec;29(12):1027-1034. doi: 10.1038/s41422-019-0255-3. Epub 2019 Nov 15. PMID: 31729466; PMCID: PMC6951342. |