Primary Information |
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| BoMiProt ID | Bomi7944 |
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| Protein Name | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1/PI(4)P 5-kinase-like protein 1/PtdIns(4)P-5-kinase-like protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q17QS4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069315.2 |
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| Aminoacid Length | 396 |
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| Molecular Weight | 44778 |
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| FASTA Sequence |
Download |
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| Gene Name | PIP5KL1 |
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| Gene ID | 523736 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | PIP5KL1 appears to be a potential tumour suppressor in cervical cancer development. |
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| Biochemical Properties | Two types of phosphoinositide kinase, designated type I PIPKs [also named as PIP5K (phosphatidylinositol 4- phosphate 5-kinases)], and type II PIPKs [also named as PIP4K (phosphatidylinositol 5-phosphate 4-kinases)] have been well characterized. Both type I and II PIPKs consist of a, b and c isoforms.Because of their close correlation with the development of human cancers. |
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| PTMs | Phosphorylation at Ser |
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| Additional Comments | Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells |
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| Linking IDs | Bomi7944 |
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| Bibliography | 1.Shi L, Zhao M, Luo Q, Ma YM, Zhong JL, Yuan XH, Huang CZ. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Mol Biol Rep. 2010 Jun;37(5):2189-98. doi: 10.1007/s11033-009-9701-5. Epub 2009 Aug 13. PMID: 19680787. 2.Shi L, Wang K, Zhao M, Yuan X, Huang C. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitro and in vivo. Cell Biol Int. 2010 Feb 22;34(3):309-15. doi: 10.1042/CBI20090040. PMID: 19947914. |
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| Protein Function | PIP5KL1 appears to be a potential tumour suppressor in cervical cancer development. |
|---|
| Biochemical Properties | Two types of phosphoinositide kinase, designated type I PIPKs [also named as PIP5K (phosphatidylinositol 4- phosphate 5-kinases)], and type II PIPKs [also named as PIP4K (phosphatidylinositol 5-phosphate 4-kinases)] have been well characterized. Both type I and II PIPKs consist of a, b and c isoforms.Because of their close correlation with the development of human cancers. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-26, 74-86, 310-328 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells |
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| Linking IDs | |
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| Bibliography | 1.Shi L, Zhao M, Luo Q, Ma YM, Zhong JL, Yuan XH, Huang CZ. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Mol Biol Rep. 2010 Jun;37(5):2189-98. doi: 10.1007/s11033-009-9701-5. Epub 2009 Aug 13. PMID: 19680787. 2.Shi L, Wang K, Zhao M, Yuan X, Huang C. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitro and in vivo. Cell Biol Int. 2010 Feb 22;34(3):309-15. doi: 10.1042/CBI20090040. PMID: 19947914. |
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