Primary Information | |
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BoMiProt ID | Bomi6919 |
Protein Name | Macrophage scavenger receptor types I and II/Macrophage acetylated LDL receptor I and II/CD_antigen: CD204 |
Organism | Bos taurus |
Uniprot ID | P21758 |
Milk Fraction | Whey,MFGM |
Ref Sequence ID | NP_001106711.1 |
Aminoacid Length | 453 |
Molecular Weight | 50057 |
FASTA Sequence | Download |
Gene Name | MSR1 |
Gene ID | 281311 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | MSR1 is a multifunctional phagocytic receptor, highly expressed in macrophages, involved in uptake of apoptotic cells and modified lipoproteins.Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. |
PTMs | Ubl conjugation,Disulfide bond formation, Glycosylation, Phosphorylation |
Significance of PTMs | The recruitment of TAK1/MKK7/JNK signalling complex is mediated through K63 polyubiquitylation of the macrophage scavenger receptor 1 (MSR1). K63 polyubiquitylation on phagosomal proteins is also used as a scaffold for the recruitment of signalling complexes,in particular the kinase complex TAK1/MKK7/JNK to MSR1 via specific polyubiquitylation on a conserved lysine K27. |
Linking IDs | Bomi6919 |
Bibliography | Guo M, Härtlova A, Gierliński M, Prescott A, Castellvi J, Losa JH, Petersen SK, Wenzel UA, Dill BD, Emmerich CH, Ramon Y Cajal S, Russell DG, Trost M. Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages. EMBO J. 2019 Jun 3;38(11):e100299. doi: 10.15252/embj.2018100299. Epub 2019 Apr 26. PMID: 31028084; PMCID: PMC6545745. |
Protein Function | MSR1 is a multifunctional phagocytic receptor, highly expressed in macrophages, involved in uptake of apoptotic cells and modified lipoproteins.Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. |
PTMs | Ubl conjugation,Disulfide bond formation, Glycosylation, Phosphorylation |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P21758|MSRE_BOVIN Macrophage scavenger receptor types I and II OS=Bos taurus OX=9913 GN=MSR1 PE=1 SV=1 MAQWDDFPDQQEDTDSCTESVKFDARSVTALLPPHPKNGPTLQERMKSYKTALITLYLIV FVVLVPIIGIVAAQLLKWETKN*82CTVGSVNADISPSPEGKGN*101GSEDEMRFREAVMERMSNM ESRIQYLSDNEANLLDAKNFQN*142FSITTDQRFNDVLFQLNSLLSSIQEHENIIGDISKSLV GLN*183TTVLDLQFSIETLNGRVQENAFKQQEEMRKLEERIYN*220ASAEIKSLDEKQVYLEQEIK GEMKLLNN*248ITNDLRLKDWEHSQTLKN*266ITLLQGPPGPPGEKGDRGPPGQNGIPGFPGLIGT PGLKGDRGISGLPGVRGFPGPMGKTGKPGLNGQKGQKGEKGSGSMQRQSNTVRLVGGSGP HEGRVEIFHEGQWGTVCDDRWELRGGLVVCRSLGYKGVQSVHKRAYFGKGTGPIWLNEVF CFGKESSIEECRIRQWGVRACSHDEDAGVTCTT |
Predicted Disorder Regions | 1-20, 35-44, 93-104, 226-232, 268-313, 333-337, 352-355 |
DisProt Annotation | Disorder content 11% Term disorder, Fragment 1 - 50 Term protein binding , Fragment 1 - 50 Term molecular sequestering activity, Fragment 1 - 50 |
TM Helix Prediction | 1TMH; (53-75) |
Significance of PTMs | The recruitment of TAK1/MKK7/JNK signalling complex is mediated through K63 polyubiquitylation of the macrophage scavenger receptor 1 (MSR1). K63 polyubiquitylation on phagosomal proteins is also used as a scaffold for the recruitment of signalling complexes,in particular the kinase complex TAK1/MKK7/JNK to MSR1 via specific polyubiquitylation on a conserved lysine K27. |
Linking IDs | |
Bibliography | Guo M, Härtlova A, Gierliński M, Prescott A, Castellvi J, Losa JH, Petersen SK, Wenzel UA, Dill BD, Emmerich CH, Ramon Y Cajal S, Russell DG, Trost M. Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages. EMBO J. 2019 Jun 3;38(11):e100299. doi: 10.15252/embj.2018100299. Epub 2019 Apr 26. PMID: 31028084; PMCID: PMC6545745. |