Primary Information |
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| BoMiProt ID | Bomi3702 |
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| Protein Name | Adenylyltransferase and sulfurtransferase MOCS3/Molybdenum cofactor synthesis protein 3/Sulfur carrier protein MOCS2A sulfurtransferase/Sulfurtransferase MOCS3/Molybdopterin-synthase sulfurtransferase/Sulfur carrier protein MOCS2A adenylyltransferase |
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| Organism | Bos taurus |
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| Uniprot ID | A1A4L8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001075203.1 |
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| Aminoacid Length | 455 |
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| Molecular Weight | 48834 |
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| FASTA Sequence |
Download |
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| Gene Name | MOCS3 |
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| Gene ID | 539728 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | take part in molybdopterin biosynthesis and Cofactor biosynthesis. |
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| Biochemical Properties | Binds 1 zinc ion per subunit.MOCS3 structurally and functionally resembles the ubiquitin-activating enzyme E1.The C-terminus of MOCS3 has a rhodanese-like fold and transfer sulfur to be transferred to MOCS2A(subunit of MPT synthase) in the form of a persulfide group. |
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| PTMs | Disulfide formation |
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| Linking IDs | Bomi3702 |
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| Bibliography | Neukranz Y, Kotter A, Beilschmidt L, Marelja Z, Helm M, Gräf R, Leimkühler S. Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome. Biochemistry. 2019 Apr 2;58(13):1786-1798. doi: 10.1021/acs.biochem.8b01160. Epub 2019 Mar 13. PMID: 30817134. |
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| Protein Function | take part in molybdopterin biosynthesis and Cofactor biosynthesis. |
|---|
| Biochemical Properties | Binds 1 zinc ion per subunit.MOCS3 structurally and functionally resembles the ubiquitin-activating enzyme E1.The C-terminus of MOCS3 has a rhodanese-like fold and transfer sulfur to be transferred to MOCS2A(subunit of MPT synthase) in the form of a persulfide group. |
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| PTMs | Disulfide formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Linking IDs | |
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| Bibliography | Neukranz Y, Kotter A, Beilschmidt L, Marelja Z, Helm M, Gräf R, Leimkühler S. Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome. Biochemistry. 2019 Apr 2;58(13):1786-1798. doi: 10.1021/acs.biochem.8b01160. Epub 2019 Mar 13. PMID: 30817134. |
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