Primary Information | |
---|---|
BoMiProt ID | Bomi3702 |
Protein Name | Adenylyltransferase and sulfurtransferase MOCS3/Molybdenum cofactor synthesis protein 3/Sulfur carrier protein MOCS2A sulfurtransferase/Sulfurtransferase MOCS3/Molybdopterin-synthase sulfurtransferase/Sulfur carrier protein MOCS2A adenylyltransferase |
Organism | Bos taurus |
Uniprot ID | A1A4L8 |
Milk Fraction | Whey |
Ref Sequence ID | NP_001075203.1 |
Aminoacid Length | 455 |
Molecular Weight | 48834 |
FASTA Sequence | Download |
Gene Name | MOCS3 |
Gene ID | 539728 |
Protein Existence Status | reviewed |
Secondary Information | |
Protein Function | take part in molybdopterin biosynthesis and Cofactor biosynthesis. |
Biochemical Properties | Binds 1 zinc ion per subunit.MOCS3 structurally and functionally resembles the ubiquitin-activating enzyme E1.The C-terminus of MOCS3 has a rhodanese-like fold and transfer sulfur to be transferred to MOCS2A(subunit of MPT synthase) in the form of a persulfide group. |
PTMs | Disulfide formation |
Linking IDs | Bomi3702 |
Bibliography | Neukranz Y, Kotter A, Beilschmidt L, Marelja Z, Helm M, Gräf R, Leimkühler S. Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome. Biochemistry. 2019 Apr 2;58(13):1786-1798. doi: 10.1021/acs.biochem.8b01160. Epub 2019 Mar 13. PMID: 30817134. |
Protein Function | take part in molybdopterin biosynthesis and Cofactor biosynthesis. |
Biochemical Properties | Binds 1 zinc ion per subunit.MOCS3 structurally and functionally resembles the ubiquitin-activating enzyme E1.The C-terminus of MOCS3 has a rhodanese-like fold and transfer sulfur to be transferred to MOCS2A(subunit of MPT synthase) in the form of a persulfide group. |
PTMs | Disulfide formation |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
Predicted Disorder Regions | NA |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
Linking IDs | |
Bibliography | Neukranz Y, Kotter A, Beilschmidt L, Marelja Z, Helm M, Gräf R, Leimkühler S. Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome. Biochemistry. 2019 Apr 2;58(13):1786-1798. doi: 10.1021/acs.biochem.8b01160. Epub 2019 Mar 13. PMID: 30817134. |