Primary Information |
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| BoMiProt ID | Bomi3634 |
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| Protein Name | Active breakpoint cluster region-related protein |
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| Organism | Bos taurus |
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| Uniprot ID | A6QNS3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039669.2 |
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| Aminoacid Length | 859 |
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| Molecular Weight | 97612 |
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| FASTA Sequence |
Download |
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| Gene Name | ABR |
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| Gene ID | 515556 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity.ABR mRNA is highly enriched in the brain.GTPase-activating proteins that increases GTPase activity of Rac1 and CDC42. |
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| PTMs | phosphorylation on Ser |
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| Linking IDs | Bomi3634 |
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| Bibliography | Tan EC, Leung T, Manser E, Lim L. The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. J Biol Chem. 1993 Dec 25;268(36):27291-8. PMID: 8262969. |
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| Protein Function | Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity.ABR mRNA is highly enriched in the brain.GTPase-activating proteins that increases GTPase activity of Rac1 and CDC42. |
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| PTMs | phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QNS3|ABR_BOVIN Active breakpoint cluster region-related protein OS=Bos taurus OX=9913 GN=ABR PE=2 SV=1
MEPLSHRGLPRLSWIDTLYSNFSYGADDYDAEGNEEQKGPPEGSETMPYIDESPTMS*57PQL
SARSQGGGDSISPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPL
KATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSRDSHTSVTMEALLYKPI
DRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETR
QLVKDGFLVEVSEGSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLL
NSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCF
KLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKT
RVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDP
QTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQSGVFGVKISVVTKRERSKV
PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGT
LKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLK
RVAEKEPVNKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQH
PPISFAELKRNTLYFSTDV
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| Predicted Disorder Regions | 10-84, 633-641 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Linking IDs | |
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| Bibliography | Tan EC, Leung T, Manser E, Lim L. The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. J Biol Chem. 1993 Dec 25;268(36):27291-8. PMID: 8262969. |
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