Primary Information |
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| BoMiProt ID | Bomi9976 |
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| Protein Name | Transketolase-like protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2NKZ4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039490.1 |
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| Aminoacid Length | 626 |
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| Molecular Weight | 67501 |
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| FASTA Sequence |
Download |
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| Gene Name | TKTL2 |
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| Gene ID | 509186 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Responsible for generating sugar phosphates for intracellular nucleotide metabolism as well as for the production of nicotinamide adenine dinucleotide phosphate (NADPH), a reducing agent and anti-oxidant.Links the pentose phosphate pathway (PPP), a non-oxidative glucose pathway (NOGP), to glycolysis. |
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| Biochemical Properties | homodimer and known thiamine diphosphate (TDP)-dependent enzyme that possesses two active sites located at the monomer contact surfaces.Ca2+,Mn2+ and Co2+ as cofactors. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Deshpande GP, Patterton HG, Faadiel Essop M. The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases. BMC Struct Biol. 2019 Jan 15;19(1):2. doi: 10.1186/s12900-018-0099-y. PMID: 30646877; PMCID: PMC6334435. |
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