Primary Information |
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| BoMiProt ID | Bomi9964 |
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| Protein Name | Transforming growth factor-beta receptor-associated protein 1/
TGF-beta receptor-associated protein 1/TRAP-1/TRAP1 |
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| Organism | Bos taurus |
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| Uniprot ID | A7MB11 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001095478.1 |
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| Aminoacid Length | 859 |
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| Molecular Weight | 97006 |
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| FASTA Sequence |
Download |
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| Gene Name | TGFBRAP1 |
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| Gene ID | 514660 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | TRAP1 is a previously described 96-kDa cytoplasmic protein shown to bind to TGF-beta receptors and suggested to play a role in TGF-beta signaling. |
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| Biochemical Properties | Full-length TRAP1 Contains Multiple Receptor-binding Domains, and Single Domains Show Reduced Binding Specificity to establish the domains of TRAP1 involved in its binding to TbRII. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Deletion constructs of TRAP1 inhibit TGF-beta signaling and diminish the interaction of Smad4 with Smad2. |
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| Bibliography | 1.Wurthner JU, Frank DB, Felici A, Green HM, Cao Z, Schneider MD, McNally JG, Lechleider RJ, Roberts AB. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem. 2001 Jun 1;276(22):19495-502. doi: 10.1074/jbc.M006473200. Epub 2001 Feb 20. PMID: 11278302. 2. |
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