Primary Information |
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BoMiProt ID | Bomi9941 |
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Protein Name | Transcription factor Maf |
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Organism | Bos taurus |
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Uniprot ID | A7Z017 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001099107.1 |
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Aminoacid Length | 377 |
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Molecular Weight | 38987 |
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FASTA Sequence |
Download |
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Gene Name | MAF |
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Gene ID | 782481 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | transcriptional activator or repressor.When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Activates the expression of IL4 in T-helper 2 (Th2) cells. |
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PTMs | Phosphorylation and ubiquitination |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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Predicted Disorder Regions | 8 disordered segments; (2-18), (29-41), (51-115), (126-163), (179-197), (223-246), (262-268), (301-309) |
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DisProt Annotation | |
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TM Helix Prediction | no TM helices |
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Significance of PTMs | Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids (By similarity).By similarity
Phosphorylated by GSK3 and MAPK13 on serine and threonine residues (Probable). The phosphorylation status can serve to either stimulate or inhibit transcription |
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Bibliography | Liu M, Zhao X, Ma Y, Zhou Y, Deng M, Ma Y. Transcription factor c-Maf is essential for IL-10 gene expression in B cells. Scand J Immunol. 2018 Sep;88(3):e12701. doi: 10.1111/sji.12701. Epub 2018 Aug 16. PMID: 29974486. |