Primary Information |
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| BoMiProt ID | Bomi9940 |
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| Protein Name | Transcription factor jun-D |
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| Organism | Bos taurus |
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| Uniprot ID | A7YY54 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001096723.1 |
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| Aminoacid Length | 347 |
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| Molecular Weight | 35352 |
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| FASTA Sequence |
Download |
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| Gene Name | JUND |
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| Gene ID | 517192 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Jun-D is involved in the activation of immediate early genes induced by growth factors and by tumor promoters. Several tumor promoter- and growth factor responsive genes are downstream of AP-1 binding sites.Ligand-induced modification of preexisting Jun-D could play a role in the activation of these genes. |
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| Biochemical Properties | Three members of the mammalian jun family jun C, jun-B, and jun-D. The three Jun proteins are closely related in amino acid sequence, particularly in the region (HR-2) containing the DNA-binding domain, the heptad leucine repeats, and domains for dimerization and interaction with Fos, and in the segment (HR-1) containing a putative transcription activation domain. |
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| Significance in milk | regulator of bovine milk fatty acid profile. |
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| PTMs | Phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7YY54|JUND_BOVIN Transcription factor JunD OS=Bos taurus OX=9913 GN=JUND PE=2 SV=1
METPFYGDEALSGLGGGGSSSGGGGSFASPGRLFPGAPPTAAPGSMMKKDALTLSLSEQV
AAALKPAAAPPPGPLRTDGAPGTAPPDGLLAS*92PELGLLKLAS*102PELERLIIQSNGLVTTT*119P
TSTQFLYPKVAASEEQEFAEGFVKALEDLHKQNQLSAGAASAAAAAGGPSGTAAGAAPPS
ELAPAAATPEAPVYANLSSYAGGTGSAGGAATVAFAAEPVPFPPPPPPGTLGPPRLAALK
DEPQTVPDVPS*251FGES*255PPLS*259PIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKV
KTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY
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| Predicted Disorder Regions | 5 disordered segments; (2-97), (123-192),(202-210), (262-294), (332-339) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Ryder K, Lanahan A, Perez-Albuerne E, Nathans D. jun-D: a third member of the jun gene family. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1500-3. doi: 10.1073/pnas.86.5.1500. PMID: 2493644; PMCID: PMC286724. |
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