Search by BoMiProt ID - Bomi9938

Primary Information

BoMiProt ID Bomi9938
Protein Name Transcription factor HES-1/Hairy and enhancer of split 1
Organism Bos taurus
Uniprot IDQ3ZBG4
Milk FractionWhey,MFGM
Ref Sequence ID NP_001029850.1
Aminoacid Length 280
Molecular Weight 29510
FASTA Sequence Download
Gene Name HES1
Gene ID 539547
Protein Existence Status reviewed

Secondary Information

Protein Function Neurogenesis & gliogenesis.May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.
Biochemical Properties Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG).
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 6 disordered segments; (1-48), (64-78), (99-104), (156-178), (199-208), (250-280)
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Dhanesh SB, Subashini C, James J. Hes1: the maestro in neurogenesis. Cell Mol Life Sci. 2016 Nov;73(21):4019-42. doi: 10.1007/s00018-016-2277-z. Epub 2016 May 27. PMID: 27233500.