Primary Information |
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| BoMiProt ID | Bomi9938 |
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| Protein Name | Transcription factor HES-1/Hairy and enhancer of split 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZBG4 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001029850.1 |
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| Aminoacid Length | 280 |
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| Molecular Weight | 29510 |
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| FASTA Sequence |
Download |
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| Gene Name | HES1 |
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| Gene ID | 539547 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Neurogenesis & gliogenesis.May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. |
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| Biochemical Properties | Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG). |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 6 disordered segments; (1-48), (64-78), (99-104), (156-178), (199-208), (250-280) |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Bibliography | Dhanesh SB, Subashini C, James J. Hes1: the maestro in neurogenesis. Cell Mol Life Sci. 2016 Nov;73(21):4019-42. doi: 10.1007/s00018-016-2277-z. Epub 2016 May 27. PMID: 27233500. |
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