Primary Information
BoMiProt ID	Bomi9937
Protein Name	Transcription factor E3
Organism	Bos taurus
Uniprot ID	Q05B92
Milk Fraction	whey
Ref Sequence ID	NP_001069279.2
Aminoacid Length	573
Molecular Weight	61498
FASTA Sequence	Download
Gene Name	TFE3
Gene ID	520800
Protein Existence Status	Reviewed
Secondary Information
Protein Function	It is a transcription factor that acts as a master regulator of lysosomal biogenesis and immune response.
PTMs	Methylation, Phsophorylation and Ubiquitinylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q05B92|TFE3_BOVIN Transcription factor E3 OS=Bos taurus OX=9913 GN=TFE3 PE=2 SV=1 MSHAAEPAQDGVEASAEGPRAVFLLLEDRRPADSAQLLSLNSLLPESGIVADIELENVLD PDSFYELKSPPLSLRSSLPISLQATPATPATLSASSSAEGSRTPAMSSSSSSRVLLRQQL MRAQAQEQERRERREQASSFPSPAPASPAISVVGVSAGGHTLGRPPPAQVPREVLKVQTH LENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGGASVQPLPTPEAAHAPGPTSS APNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGNTGLQLPSTLPVSGNL LDVYNNQGVATPAITVSNS*319CPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNI NDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRS LQLRIQELELQAQIHGLPVPPTPGLLSLAATSASDSLKPEQLDVEEEGRPGTAIFHATGG LAQSAPHQQPPPPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGTLS*540 PLRAAS*546DPLLSS*552VS*554PAVS*558KASSRRSS*566FSMEEES
Predicted Disorder Regions	1-13, 69-78, 93-131, 239-241, 343-352, 414-440, 496-511, 550-573
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Phosphorylation by MTOR regulates its subcellular location and activity. When nutrients are present, phosphorylation by MTOR promotes retention in the cytosol
Bibliography	Sato, M., Hiraoka, M., Suzuki, H., Bai, Y., Kurotani, R., Yokoyama, U., Okumura, S., Cismowski, M. J., Lanier, S. M., & Ishikawa, Y. (2011). Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator. The Journal of biological chemistry, 286(20), 17766–17776. https://doi.org/10.1074/jbc.M111.219816