Primary Information
BoMiProt ID	Bomi9929
Protein Name	Transcription factor 21/TCF-21
Organism	Bos taurus
Uniprot ID	Q5E9S3
Milk Fraction	whey
Ref Sequence ID	NP_001014899.1
Aminoacid Length	179
Molecular Weight	19658
FASTA Sequence	Download
Gene Name	TCF21
Gene ID	510873
Protein Existence Status	Reviewed
Secondary Information
Protein Function	Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types
PTMs	SUMOylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	(1-92), (174-179)
DisProt Annotation
TM Helix Prediction	no TM helices
Significance of PTMs	SUMOylation plays a critical role in mediating the high expression of TCF21 in Stromal cells and may participate in the development of endometriosis.
Bibliography	1.Zhu J, Wu P, Zeng C, Xue Q. Increased SUMOylation of TCF21 improves its stability and function in human endometriotic stromal cells†. Biol Reprod. 2021 Jul 2;105(1):128-136. doi: 10.1093/biolre/ioab038. PMID: 33693540. 2.Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166