Primary Information |
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| BoMiProt ID | Bomi9920 |
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| Protein Name | Transcription activator BRG1/ATP-dependent helicase SMARCA4/BRG1-associated factor 190A/Protein brahma homolog 1/SNF2-beta/SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 |
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| Organism | Bos taurus |
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| Uniprot ID | A7Z019 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001099084.1 |
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| Aminoacid Length | 1606 |
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| Molecular Weight | 180679 |
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| FASTA Sequence |
Download |
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| Gene Name | SMARCA4/BAF190A/ BRG1/SNF2B/ SNF2L4 |
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| Gene ID | 414274 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | functional role in transcriptional activation and repression of select genes by chromatin remodeling. |
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| Biochemical Properties | ATP binding activity.Has domain required for binding to 'Lys-15'-acetylated histone 3.BRG1 bromodomain is important for BAF recruitment to active enhancers. |
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| PTMs | Acetylation, Isopeptide bond formation, Phosphoprotein, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7Z019|SMCA4_BOVIN Transcription activator BRG1 OS=Bos taurus OX=9913 GN=SMARCA4 PE=2 SV=1
MSTPDPALGGT*11PRPGPSPGPGPSPGAMLGPSPGPSPGSAHSIMGPSPGPPSAGHPIPTQG
PGGYPQDNMHQMHKPMESMHEKGMSDDPRYTQMKGMGMRSGGHAGMGPPPSPMDQHSQGY
PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQPQMPALPPPSVSATGPGPSPGPAPPN
YSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQKLIPPQPT
GRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRIT*345PIQKPRGLDPVEILQ
EREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDT
ALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKE
YHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDK
RLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDE
T*601S*602QMS*605DLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEE
EEEEQPQPAQPPTLPVEEKKKIPDPDS*687DDVS*691EVDARHIIENAKQDVDDEYGVSQALARGL
QSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQ
TIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQL
RSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLL
LTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRL
HKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKG
KGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRI
LPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPGSE
YFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVN
SVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDET
VNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEE
EEEKMFGRGSRHRKEVDYSDS*1341LTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGP
ST*1382PTTSTRSRDKDDESKKQKKRGRPPAEKLS*1411PNPPNLTKKMKKIVDAVIKYKDSSSGRQL
SEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNL
EGSLIYEDSIVLQSVFTSVRQKIEKEDDS*1529EGEES*1534EEEEEGEEEGS*1545ESESRSVKVKIKLGR
KEKAQDRLKGGRRRPSRGSRAKPVVS*1586DDDS*1590EEEQEEDRSGSGSEED
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| Predicted Disorder Regions | 653-683, 1531-1545, 1577-1602 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Neuronal activities induce BRG1 phosphorylation at S1382, which depends on CAMKII.BRG1 phosphorylation regulates BAF interactions with transcription co-factors. |
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| Bibliography | Kim B, Luo Y, Zhan X, Zhang Z, Shi X, Yi J, Xuan Z, Wu J. Neuronal activity-induced BRG1 phosphorylation regulates enhancer activation. Cell Rep. 2021 Jul 13;36(2):109357. doi: 10.1016/j.celrep.2021.109357. PMID: 34260936; PMCID: PMC8315893. |
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