Primary Information |
|---|
| BoMiProt ID | Bomi9893 |
|---|
| Protein Name | Tonsoku-like protein/Inhibitor of kappa B-related protein/I-kappa-B-related protein/IkappaBR/NF-kappa-B inhibitor-like protein 2/Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q0P5G1 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001068656.1 |
|---|
| Aminoacid Length | 1374 |
|---|
| Molecular Weight | 150245 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | TONSL/IKBR/ NFKBIL2 |
|---|
| Gene ID | 505102 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | function as regulators of the NF-kappaB family of transcription factors. |
|---|
| Biochemical Properties | Most members of the NF-kB family can form homo- or heterodimers (except for RelB, which only forms heterodimers with p50 or p52) that bind slightly different kB motifs. |
|---|
| PTMs | Methylation,Phosphorylation at Ser |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0P5G1|TONSL_BOVIN Tonsoku-like protein OS=Bos taurus OX=9913 GN=TONSL PE=2 SV=1
MSLERELRQLSKAKTKAQRSGQLREEASVCHQLGELLASHGCYAEALREHQQELQLLETT
DDPLGCAVAHRKIGERLAEMEDYSAALQHQHRYLELACALSNHVEQQRAWATIGRTHLDI
YDHHQSQDALQQAQDAFEKSLAILDEKLQGSLPKRELSEMRTRIYLNLGLTCESLQQVAL
CSAYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRRGQHSQAMRCLEGARECARVLKQAFL
ESECCLLLSQVLLDLGDFLAAKRALKKAYRLGSQKPLQKASVCRTLKYVLAVVQLQQRLE
ESEESDPEVAMGICEQLGDLFSKAGDFPKAAAAYQKQLRFAELLSRPGPELAVIHVSLAA
TLGDMKDHRQAVHHYEAELKLQEGNPLEEAKTWLNIALSREEAGDAYEVLALCFQKALGC
AQLAGQPQLQRQILQHLHAVQLRLQPQEAPSTETRLQELKAAGDEDEGDGEDEEDEEDDD
ALEATELELSESENEADASPPLEEDEELRGCLGRQRVNKWSRRNDVGETLLHRACIEGQL
GRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLDIVRFLLDHGAAVDDPGGQGCDGITPL
HDALNCGHFEVAELLIERGASVTLRTRKGHNPLETLQQWVKLYGKDLDSETQEKAAAMGR
LLQAASLGRAPHSSQAPQTLPSNHLFDPETSPPSSPCPGTPEVCEASTRVS*711QGLAVSTVA
RPRRSRHKVASSSSSEGEDSAGPSQPTQKRPRHASPSLQTKAPMPGPASDREAATTSTSW
AAYREAIRGVGSAQTCRLGPSPLRGPSEIPIPQAALIPQEECLAGDWLEEDFPMSPGHRG
RCPARPQSSGDGGRHRASGPGSDTARRPRAQARQSRLPYLESWSTPVRADRANSQATEPA
RSPDVPRVVAPTGENPTTGHLPGQVLPPPIRVRVRVQDNLFLIPVPHREAHSVAWLAEQA
AQRHYQASGLLPRLSLQKEGALLAPQDPIPDVLQSNEEVLAEVTSWDLPPLRDRYRRACQ
TLEQGEHQQVLQAVEHQGSAPTFSACSLALRQAQLTPLLRALKLHSALRELRLAGNRLGD
GCVAELLATLDTVPGLTLLDLSSNHLGPEGLRQLAAGLLGQTTLQNLEELDLSMNPLGDG
CGQALASILRACPVLCTLHLQACGFGPGFFLSHQVALGSAFQDTKCLKTLSLSYNGLGPT
ALGPVLGSLPAHSLLRLELSSVVTGKSDVGLTDPVVHYLSQEGCVLEHLSLSANHLGDKD
VRALSRCLPLCPSLVSLDLSANPEVSSAGLEELLSTLQKRPQGLSFLGLSGCAVQGPLGL
DLWDKVVAQLQELQLCTRRLSAEDRNALHQLLPSQLGPKVCTLDQGPKLFFRHL
|
|---|
| Predicted Disorder Regions | 438-504, 678-689, 736-739, 882-888 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Additional Comments | IkappaBR can aid activation of select NF-kappaB-regulated genes by sequestering p50 homodimers. |
|---|
| Bibliography | 1.Ray P, Yang L, Zhang DH, Ghosh SK, Ray A. Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR. J Biol Chem. 1997 Aug 8;272(32):20191-7. doi: 10.1074/jbc.272.32.20191. PMID: 9242696. |
|---|
