Search by BoMiProt ID - Bomi9892


Primary Information

BoMiProt ID Bomi9892
Protein Name Toll-like receptor 6/CD_antigen: CD286
Organism Bos taurus
Uniprot IDQ704V6
Milk FractionExosomes
Ref Sequence ID NP_001001159.1
Aminoacid Length 793
Molecular Weight 90927
FASTA Sequence Download
Gene Name TLR6
Gene ID 407237
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells Highest expression levels seen in blood and lymph node, intermediate expression seen in spleen and lowest expression seen in the liver, lung and udder cistern.
Protein Function TLRs have the ability to initiate inflammatory responses and they also have roles in the proliferation, regulation, and survival of immune cells
Biochemical Properties TLRs, which are transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail, are known as innate immunity receptors that are essential for detecting invading pathogens and are associated with altered susceptibility to many diseases, including cancers.
PTMs Disulfide bond formation,N-linked Glycosylation at Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q704V6|TLR6_BOVIN Toll-like receptor 6 OS=Bos taurus OX=9913 GN=TLR6 PE=2 SV=1 MIKDKESPIRSCHFVYIVALVFGTIIQFSDESEFVVDMSKTSLIHVPKDLPPKTKVLDLS QNN*63ISELHLSDISFLSGLRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQLQKISCHPI TTTLKHLDLSFNDFDALPICKEFGN*145LTQLNFLGLSATKLQQLDLLPIAHLHLSCILLDLE DYMKENKKESLQILNTKKLHLVFHPNSFFSVQVDISANSLGCLQLTNIKLNDYNCQVLLK FLSGLTGGPTLLN*253FTLNHVETTWKCLVKVFQFLWPKPIEYLNIYN*285LTIVESIDEEVFTYY KTTLKALKIEHITNKVFIFSQTALYTVFSEMNILMLTISDTRFIHMLCPQEPSTFKFLN*359F TQNSFTDSVFQNCDTLARLETLILQKNELKDLFKTSLMTKDMLSLETLDVSWNSLEYDRS NGN*423CSWVGSIVVLN*434LSSNALTDSVFRCLPPRIKVLDLHNNRIRSIPKDVTGLETLQELNL ASNSLAHLPGCGIFSSLSILIIEHNSISNPSADFFQSCQKIRSLKAGNNPFQCSCELRDF IQSVGQVSSDVVEGWPESYKCDYPESYKGTPLKDFQVSELSCNTALLIITIVVPGLVLAV AVTVLCIYLDLPWYLRMVCQWTQTRRRARNVPLEELQRTLQFHAFISYSEHDSAWVKNEL IPNLEKEDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH HNLFHEGSDNLILILLDPIPQYSIPSSYHKLRALMAQRTYLEWPKEKSKHGLFWANLRAS INIKLMEKAAEIH
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 2TMHs; (7-29),(587-609)
Bibliography 1.Toll-like receptors and cancer, particularly oral squamous cell carcinoma.Rich AM, Hussaini HM, Parachuru VP, Seymour GJ.Front Immunol. 2014; 5():464. 2.Opsal MA, Våge DI, Hayes B, Berget I, Lien S. Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10. Gene. 2006 Dec 15;384:45-50. doi: 10.1016/j.gene.2006.06.027. Epub 2006 Jul 29. PMID: 16950576. 3.Semlali A, Reddy Parine N, Arafah M, Mansour L, Azzi A, Al Shahrani O. et al. Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-kappaB Mediated Inflammation in Colon Cancer Patients. PLoS One. 4.Gu J, Liu Y, Xie B, Ye P, Huang J, Lu Z. Roles of toll-like receptors: From inflammation to lung cancer progression. Biomed Rep. 2018;8:126–32. 2016;11:e0146333. 5.Bhatelia K, Singh K, Singh R. TLRs: linking inflammation and breast cancer. Cell Signal. 2014;26:2350–7. 6.Liu YD, Ji CB, Li SB, Yan F, Gu QS, Balic JJ. et al. Toll-like receptor 2 stimulation promotes colorectal cancer cell growth via PI3K/Akt and NF-kappaB signaling pathways. Int Immunopharmacol. 2018;59:375–83. 7. Xu C, Li H, Yin M, Yang T, An L, Yang G. Osteopontin is involved in TLR4 pathway contributing to ovarian cancer cell proliferation and metastasis. Oncotarget. 2017;8:98394–404.