Primary Information
BoMiProt ID	Bomi9841
Protein Name	Thyroxine 5-deiodinase/5DIII DIOIII/Type 3 DI/Type III iodothyronine deiodinase
Organism	Bos taurus
Uniprot ID	Q5I3B1
Milk Fraction	whey
Ref Sequence ID	NP_001010993.2
Aminoacid Length	301
Molecular Weight	33888
FASTA Sequence	Download
Gene Name	DIO3
Gene ID	494549
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	Highly expressed in mammary gland
Protein Function	It is responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine)
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	1TMH; (42-64)
Bibliography	Yang, W., Li, D., Wang, G., Wu, X., Zhang, M., Zhang, C., Cui, Y., & Li, S. (2017). Expression and imprinting of DIO3 and DIO3OS genes in Holstein cattle. Journal of genetics, 96(2), 333–339. https://doi.org/10.1007/s12041-017-0780-0