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Primary Information | |
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| BoMiProt ID | Bomi9831 |
| Protein Name | Thymosin beta-10/Thymosin beta-9 |
| Organism | Bos taurus |
| Uniprot ID | P21752 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_777048.1 |
| Aminoacid Length | 42 |
| Molecular Weight | 4805 |
| FASTA Sequence | Download |
| Gene Name | TMSB10 |
| Gene ID | 282385 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | The 5 Kd (MW), retinoic acid responsive thymosin beta-10 protein is expressed at relatively high levels in embryonic tissues, and its mRNA is abundant in a variety of tumors and tumor cell lines.intracellular G-actin binding protein.plasmid-driven overexpression of thymosin beta-10 gene results in increased susceptibility of permanently transfected fibroblasts to undergo apoptosis.The presence of increased cytoplasmic thymosin beta-10 precipitated significant disruption of phalloidin-stained actin stress fibers while knockout of thymosin expression promoted F-actin assembly.controlling apoptosis possibly by acting as an actin-mediated tumor suppressor. |
| PTMs | Acetylation on Lys and Ala, Phosphorylation on Ser and Thr |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P21752|TYB10_BOVIN Thymosin beta-10 OS=Bos taurus OX=9913 GN=TMSB10 PE=1 SV=2 MADKPDLGEINS*12FDKAKLKKT*21ET*23QEKNTLPTKETIEQEKQAK |
| CATH | Matched CATH superfamily 1.20.5.520 |
| Predicted Disorder Regions | Entirely disordered from 1 to 42 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1HJ0, |
| Bibliography | Hall AK. Thymosin beta-10 accelerates apoptosis. Cell Mol Biol Res. 1995;41(3):167-80. PMID: 8589757. |