Primary Information |
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| BoMiProt ID | Bomi9820 |
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| Protein Name | Thrombospondin-4 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SWW8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029900.1 |
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| Aminoacid Length | 961 |
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| Molecular Weight | 105974 |
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| FASTA Sequence |
Download |
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| Gene Name | THBS4 |
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| Gene ID | 541281 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | role in ECM remodeling and formation of “transitional matrix”.also participates in wound healing and scar formation.regulates the production and assembly of collagen and organization, repair, and remodeling of ECM.enhances vesicular trafficking of dystrophin-glycoprotein and integrin attachment complexes to stabilize the sarcolemma.Enhances vesicular trafficking of dystrophin-glycoprotein and integrin attachment complexes to stabilize the sarcolemma.Required for angiogenesis by TGF beta pathway. |
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| Biochemical Properties | The oligimerization of the subunits to form the TSP-4 pentamer.four EGF-like repeats,also contains type 3 ca+2 binding domain,coiled coil domain which is responsible for pentamerization. |
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| Significance in milk | Bone formation |
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| PTMs | Disulfide bond formation,Glycosylation,ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3SWW8|TSP4_BOVIN Thrombospondin-4 OS=Bos taurus OX=9913 GN=THBS4 PE=2 SV=1
MLAPRGATFLLLHLALQPWLGAGAQATPQVFDLLPSASQRLNPSVLQPILTDPTLNELYV
ISTFKLQSKSSATIFGLYSSADHSKYFEFTVMGRLNKAILRYLKNDGRIHLVVFNNLQLA
DGRRHRLLLRLTNLHRGAGSVELFLDCTRVDSIHNLPRAFSGLAQSPEAVELRTFQRKAH
DSLEELKLVVRGSLIQVASLQDCFLQQSEPLATTNTGDFNRQFLGQMSQLNQLLGEVKDL
LRQQVKETSFLRNTIAECQACGPLSFQSPTPNTLMPVVPAASPTPPVRRCDSNPCFRGVR
CTDTRDGFQCGPCPEGYTGNGIVCSDVDECRYHPCYPGVRCVNLAPGFRCDACPVGFTGP
MMQGVGISFAKTNKQVCTDIDECRNGACVLNSICINTLGSYRCGPCKPGYIGDQMRGCKM
ERNCRDPELNPCSVNAQCIEERQGDVTCVCGVGWAGDGYICGKDVDIDSYPDEELPCSAR
NCKKDNCKYVPNSGQEDADRDGIGDACDDDADGDGILNEQDNCVLTHNVDQRNSDKDIFG
DACDNCRNVLNNDQKDTDGDGKGDACDDDMDGDGIKNILDNCQKVPNSDQEDRDGDGVGD
ACDSCPEVSNPN*612QSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSAQLDTDKDGIG
DECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNSDGVGDICEADFDQDQVIDRIDVCP
ENAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVD
FEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVK
SKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYE
GSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCN*941DTIPEDFQEFQTQNFDRLD
K
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| Predicted Disorder Regions | 558-711 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | poly ubl conjugation on Lys 216 for proteosomal degradation. |
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| Bibliography | Stenina-Adognravi O, Plow EF. Thrombospondin-4 in tissue remodeling. Matrix Biol. 2019 Jan;75-76:300-313. doi: 10.1016/j.matbio.2017.11.006. Epub 2017 Nov 11. PMID: 29138119; PMCID: PMC6005712. |
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