Primary Information |
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| BoMiProt ID | Bomi9816 |
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| Protein Name | Three prime repair exonuclease 1 isoform b |
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| Organism | Bos taurus |
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| Uniprot ID | Q9BG99 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 315 |
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| Molecular Weight | 33132 |
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| FASTA Sequence |
Download |
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| Gene Name | TREX1 |
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| Gene ID | 282099 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | most abundant 3'→5' exonuclease in mammalian cells. digests single-stranded DNA (ssDNA).It has been suggested that TREX1 degrades HIV-1 DNA to enable the virus to evade the innate immune system.Trex1 is an upstream regulator of radiation-driven anti-tumour immunity.They can transport L-lactate and pyruvate across the plasma membrane. |
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| Biochemical Properties | 304 aa long. three conserved motifs that likely generate the exonuclease active site in these enzymes. |
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| PTMs | Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q9BG99|TREX1_BOVIN Three-prime repair exonuclease 1 OS=Bos taurus OX=9913 GN=TREX1 PE=1 SV=1
MGSRALPPGPVQTLIFLDLEATGLPFSQPKITELCLLAVHRYALEGLSAPQGPSPTAPVP
PRVLDKLSLCVAPGKVCS*78PAASEITGLSTAVLAAHGRRAFDADLVNLIRTFLQRQPQPWC
LVAHNGDRYDFPLLRAELALLGLASALDDAFCVDSIAALKALEPTGS*167SSEHGPRKSYSLG
SVYTRLYGQAPPDSHTAEGDVLALLSVCQWRPRALLRWVDAHAKPFSTVKPMYVITTSTG
TNPRPSAVTATVPLARASDTGPNLRGDRSPKPAPSPKMCPGAPPGEGLLAPLGLLAFLTL
AVAMLYGLSLAMPGQ
|
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| Predicted Disorder Regions | 4 disordered segments; (1-7), (48-60), (166-174), (243-284) |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH ;(288-310) |
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| Bibliography | Mazur DJ, Perrino FW. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60. doi: 10.1074/jbc.274.28.19655. PMID: 10391904. |
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