Search by BoMiProt ID - Bomi9811

Primary Information

BoMiProt ID Bomi9811
Protein Name Thioredoxin-dependent peroxide reductase, mitochondrial/Antioxidant protein 1/Thioredoxin-dependent peroxiredoxin 3/Protein SP-22
Organism Bos taurus
Uniprot IDP35705
Milk FractionWhey
Ref Sequence ID NP_776857.1
Aminoacid Length 257
Molecular Weight 28195
FASTA Sequence Download
Gene Name PRDX3
Gene ID 281998
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells liver, renal cortex and medulla,adrenal cortex and medulla
Protein Function Prx3 plays an essential role in maintaining adipose tissue integrity and sustaining whole body metabolism.
PTMs N6-Acetylation at Lys, Disulfide bond formation, Lipoylation, Palmitoylation, Phosphorylation at Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : Alpha and beta proteins (a/b)
Fold : Thioredoxin fold
Superfamily : Thioredoxin-like
Family : Glutathione peroxidase-like
Domain Name : 1ZYE A:2-163

CATH Matched CATH superfamily
Predicted Disorder Regions 234-257
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation reduces perodixase activity.The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
PDB ID 1ZYE, 4MH2, 4MH3,
Additional Comments Transient overexpression of PRDX3 suppresses the sensitivity of FA-G cells to H2O2, and decreased PRDX3 expression increases sensitivity to mitomycin C. 
Bibliography 1.Watabe S, Kohno H, Kouyama H, Hiroi T, Yago N, Nakazawa T. Purification and characterization of a substrate protein for mitochondrial ATP-dependent protease in bovine adrenal cortex. J Biochem. 1994 Apr;115(4):648-54. doi: 10.1093/oxfordjournals.jbchem.a124390. PMID: 8089078. 2.Mukhopadhyay SS, Leung KS, Hicks MJ, Hastings PJ, Youssoufian H, Plon SE. Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. J Cell Biol. 2006 Oct 23;175(2):225-35. doi: 10.1083/jcb.200607061. PMID: 17060495; PMCID: PMC2064564. 3.Huh JY, Kim Y, Jeong J, Park J, Kim I, Huh KH, Kim YS, Woo HA, Rhee SG, Lee KJ, Ha H. Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression. Antioxid Redox Signal. 2012 Feb 1;16(3):229-43. doi: 10.1089/ars.2010.3766. Epub 2011 Oct 17. PMID: 21902452; PMCID: PMC3234662. 4.