Search by BoMiProt ID - Bomi9809

Primary Information

BoMiProt ID Bomi9809
Protein Name Thioredoxin reductase 2, mitochondrial/Thioredoxin reductase TR3
Organism Bos taurus
Uniprot IDQ9N2I8
Milk FractionWhey
Aminoacid Length 511
Molecular Weight 54670
FASTA Sequence Download
Gene Name TXNRD2/TRXR2
Gene ID 282389
Protein Existence Status reviewed

Secondary Information

Protein Function  maintenance of cellular redox homeostasis in the mitochondria.
Biochemical Properties The active site is a redox-active disulfide bond. Converts [Thiolredoxin]-dithiol to [thioredoxin]-disulfide.NADP+ dependent enzyme.The selenocysteine residue is also essential for catalytic activity. Rat mitochondrial thioredoxin reductase has subunits of about 54 kDa in SDS-PAGE.Mitochondrial thioredoxin reductase is able to reduce chemically unrelated compounds such as DTNB,Selenite,alloxan,in addition to its natural substrate thioredoxin.Also active in reducing protein disulfide isomerase of both microsomal and mitochondrial origin.four-amino acid motif, Gly-Cys-Sec-Gly functions as the third redox centre of the enzyme.
PTMs Disulfide bond formation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Watabe S, Makino Y, Ogawa K, Hiroi T, Yamamoto Y, Takahashi SY. Mitochondrial thioredoxin reductase in bovine adrenal cortex its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine. Eur J Biochem. 1999 Aug;264(1):74-84. doi: 10.1046/j.1432-1327.1999.00578.x. PMID: 10447675. 2.Alberto Bindoli, Maria Pia Rigobello,[28] - Mitochondrial Thioredoxin Reductase and Thiol Status,Editor(s): Helmut Sies, Lester Packer,Methods in Enzymology,Academic Press,Volume 347, 2002,Pages 307-316