Primary Information
BoMiProt ID	Bomi9771
Protein Name	Testin
Organism	Bos taurus
Uniprot ID	Q2YDE9
Milk Fraction	Whey
Ref Sequence ID	NP_001039855.1
Aminoacid Length	421
Molecular Weight	48049
FASTA Sequence	Download
Gene Name	TES
Gene ID	534965
Protein Existence Status	reviewed
Secondary Information
Protein Function	regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization,role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. maintain Sertoli-Sertoli junctions.
Biochemical Properties	Zinc finger of LIM domain is essential for interaction with partner proteins.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	3-5, 133-171, 190-226
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Magno AL, Ingley E, Brown SJ, Conigrave AD, Ratajczak T, Ward BK. Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling. Biochem Biophys Res Commun. 2011 Sep 9;412(4):584-9. doi: 10.1016/j.bbrc.2011.07.132. Epub 2011 Aug 6. PMID: 21843504. 2.Su L, Wang Z, Xie S, Hu D, Cheng YC, Mruk DD, Guan Y. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization. J Cell Physiol. 2020 Sep;235(9):6127-6138. doi: 10.1002/jcp.29541. Epub 2020 Jan 24. PMID: 31975378.