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Primary Information | |
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| BoMiProt ID | Bomi9734 |
| Protein Name | T-complex protein 1 subunit zeta/CCT-zeta |
| Organism | Bos taurus |
| Uniprot ID | Q3MHL7 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001029714.1 |
| Aminoacid Length | 531 |
| Molecular Weight | 57956 |
| FASTA Sequence | Download |
| Gene Name | CCT6A |
| Gene ID | 521540 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Protein Function | Chaperonins, belonging to the T-complex protein-1 (TCP-1) family, assist in the correct folding of nascent and misfolded proteins. It is well-known that in mammals, the zeta subunit of the TCP-1 complex (TCP-1ζ) plays a vital role in the folding and assembly of cytoskeleta proteins. |
| Biochemical Properties | In mammals, the group II chaperonins have been composed of a hetero-oligomeric double ring complex with eight different subunits per ring, that is, TCP-1α, β, γ, δ, ε, ζ, η, and θ. These are also referred to as the TCP-1 ring complex.Each of the eight subunits has three domains, two of which specifically bind ATP and unfolded polypeptides, and a third links the first two domains thus facilitating their movement during binding. |
| PTMs | N6-acetylation at Lysine, Isopeptide bond formation, Phosphorylation at Ser, Ubl conjugation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q3MHL7|TCPZ_BOVIN T-complex protein 1 subunit zeta OS=Bos taurus OX=9913 GN=CCT6A PE=1 SV=3 MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDG NVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIT EGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIK KQDEPIDLFMVEIMEMKHKSETDTS*205LIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYE KTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPF SLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEKF TFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAE ALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGVD LNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 3IYG, 4B2T, |
| Bibliography | 1.Zhao X, Xiu J, Li Y, Ma H, Wu J, Wang B, Guo G. Characterization and Expression Pattern Analysis of the T-Complex Protein-1 Zeta Subunit in Musca domestica L (Diptera). J Insect Sci. 2017 Jul 1;17(4):90. doi: 10.1093/jisesa/iex063. PMID: 28973494; PMCID: PMC5510958. 2.Hynes G., Kubota H., Willison K. R. 1995. Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis. FEBS Lett. 358: 129–132. 3.Horwich A. L., Fenton W. A., Chapman E., Farr G. W. 2007. Two families of chaperonin: physiology and mechanism. Annu. Rev. Cell Dev. Biol. 23: 115–145. 4.Carrascosa J. L., Lorca O. L., Valpuesta J. M. 2001. Structural comparison of prokaryotic and eukaryotic chaperonins. Micron. 32: 43–50. |