Search by BoMiProt ID - Bomi9724


Primary Information

BoMiProt ID Bomi9724
Protein Name T-cell surface glycoprotein CD5/CD_antigen: CD5
Organism Bos taurus
Uniprot IDP19238
Milk FractionWhey,MFGM
Ref Sequence ID NP_776324.1
Aminoacid Length 495
Molecular Weight 54367
FASTA Sequence Download
Gene Name CD5
Gene ID 280745
Protein Existence Status reviewed

Secondary Information

Protein Function May act as a receptor in regulating T-cell proliferation. plays a pivotal role in mediating outcomes of cell survival or apoptosis, and may prevent both autoimmunity and cancer. acts as a negative regulator of TCR signaling in mature T cells.
Biochemical Properties a type-I transmembrane glycoprotein with an extracellular region composed of three scavenger receptor cysteine-rich (SRCR) domains.
PTMs Disulfide bond formation, Glycosylation, Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P19238|CD5_BOVIN T-cell surface glycoprotein CD5 OS=Bos taurus OX=9913 GN=CD5 PE=2 SV=2 MGSQHLPLAALYLLELLVTSCLGGLKVEVQGLTMRLSGSGSRCQGRLEVSN*51GTEWYAVHS QSWGQLSLYQVAPRQFLKLCQELQCRDPLLLSSSRYFKEVQFQKLIICHGQLGSFSN*117CSL NRGRQVDSLALICLEPPRTTAPPTTSPPTTTPEPTAPPRFQLVAEPGGLRCAGVVEFYSG GLGGTIGIEPQNDIKDLGQLICAALQCGSFLKPLPETEEAQTQKPEGQRPLPIRWEIQNP KCTSLEQCFRKVQPWVGGQALGLICSDFQPKVQSRLVGGSDVCEGSVEVRSGKGQKWDTL CDDSWAKGTARWEEVCREQQCGN*323VSSYRGLDPSEKTLGGFYCPPGILSRCHKLEEKKSHC KRVFVTCQN*369SSRAGLGAGAVMSIILALLLLAVLLVVCGPLAYKKVVKKFRQKKQRQWIGP TGMNQNMSFHRNHTVTVRS*439QVENATASHVENEY*453SQPPRNS*460QISAYPALEGALHRISTQPD NSS*483DS*485DYELHGAQRL
Predicted Disorder Regions 137-157, 215-228, 438-493
DisProt Annotation
TM Helix Prediction 1TMH; (380-402)
Significance of PTMs On cytoplasmic tail,contains four tyrosine residues at position 402, 453, 464, and 486 in human which are considered as phosphorylation sites.In the absence of binding of CD5 with potential ligands, TCR stimulation triggers CD5 phosphorylation on tyrosine residues and its translocation into the immunological synapse, thereby indicating a direct regulation of CD5 by TCR signals.
Bibliography 1.Domingues, R. G., Lago-Baldaia, I., Pereira-Castro, I., Fachini, J. M., Oliveira, L., Drpic, D., Lopes, N., Henriques, T., Neilson, J. R., Carmo, A. M., & Moreira, A. (2016). CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204. European journal of immunology, 46(6), 1490–1503. https://doi.org/10.1002/eji.201545663 2.Voisinne G, Gonzalez de Peredo A, Roncagalli R. CD5, an Undercover Regulator of TCR Signaling. Front Immunol. 2018 Dec 7;9:2900. doi: 10.3389/fimmu.2018.02900. PMID: 30581443; PMCID: PMC6292949.