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Primary Information | |
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| BoMiProt ID | Bomi9653 |
| Protein Name | Synembryn-A/Protein Ric-8A |
| Organism | Bos taurus |
| Uniprot ID | Q5E9J8 |
| Milk Fraction | Exosomes |
| Ref Sequence ID | NP_001015627.1 |
| Aminoacid Length | 530 |
| Molecular Weight | 59499 |
| FASTA Sequence | Download |
| Gene Name | RIC8A |
| Gene ID | 521037 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | myometrium |
| Protein Function | Resistance to inhibitors of cholinesterase 8A (Ric-8A) is a prominent non-receptor GEF and a chaperone of G protein α-subunits (Gα). |
| Biochemical Properties | Ric-8A is composed of a core armadillo-like domain and a flexible C-terminal tail. Interaction of a conserved concave surface of its core domain with the Gα C-terminus appears to mediate formation of the initial Ric-8A/GαGDP intermediate, followed by the formation of a stable nucleotide-free complex. |
| PTMs | Phosphorylation at Ser/thr |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q5E9J8|RIC8A_BOVIN Synembryn-A OS=Bos taurus OX=9913 GN=RIC8A PE=1 SV=1 MEPRAVADALETGEEDVVMEALRAYNRENSQSFTFDDAQQEDRKRLAKLLVSVLEQGLPP SRRVIWLQSIRILSRDRSCLDSFTSRRSLQALACYAGISASQGSVPEPLNMDVVLESLKC LCNLVLSSPVAQALAAEAGLVVRLAERVGLCRQSSFPHDVQFFDLRLLFLLTALRTDVRQ QLFQELQGVRLLTRALELTLGMTEGERHPELLPPQETERAMEILKVLFNITFDSIKREVD EEDAALYRHLGTLLRHCVMLAAAGDRTEELHGHAVNLLGNLPVKCLDVLLTLEPHEGSLE FLGVNMDVIRVLLSFMEKRLHQTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLR DVRTRPEVGELLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLA ARGLMAGGRPEGQYS*435EDEDT*440DT*442DEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAM KLVNMFDKLSRHRVIQPMGMS*501PRGQLTSLQDAMCETMEGQLS*522S*523DPDS*527DPD |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | 205-214, 433-451, 518-530 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 6N85, 6N86, |
| Bibliography | 1.Srivastava D, Artemyev NO. Ric-8A, a GEF, and a Chaperone for G Protein α-Subunits: Evidence for the Two-Faced Interface. Bioessays. 2020 Mar;42(3):e1900208. doi: 10.1002/bies.201900208. Epub 2020 Jan 22. PMID: 31967346; PMCID: PMC7034654. |