Search by BoMiProt ID - Bomi9631

Primary Information

BoMiProt ID Bomi9631
Protein Name Synaptogyrin-3
Organism Bos taurus
Uniprot IDA2VE58
Milk FractionWhey
Ref Sequence ID NP_001075933.1
Aminoacid Length 229
Molecular Weight 24499
FASTA Sequence Download
Gene Name SYNGR3
Gene ID 618415
Protein Existence Status reviewed

Secondary Information

Protein Function Binding of Tau to synaptic vesicles is mediated by the transmembrane vesicle protein Synaptogyrin-3 during exocytosis
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 2 disordered segments; (1-10), (191-229)
DisProt Annotation
TM Helix Prediction 4TMHs; (26-44), (70-88), (109-127) & (146-168)
Additional Comments Several neurodegenerative diseases are associated with dysfunction of Synaptogyrin-3. Fly and mouse models of Tauopathy, reduction of Synaptogyrin-3 prevents the association of presynaptic Tau with vesicles, alleviates Tau-induced defects in vesicle mobility, and restores neurotransmitter release. 
Bibliography McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P. Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. 2018 Feb 21;97(4):823-835.e8. doi: 10.1016/j.neuron.2018.01.022. Epub 2018 Feb 1. PMID: 29398363.