Primary Information |
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| BoMiProt ID | Bomi9631 |
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| Protein Name | Synaptogyrin-3 |
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| Organism | Bos taurus |
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| Uniprot ID | A2VE58 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001075933.1 |
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| Aminoacid Length | 229 |
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| Molecular Weight | 24499 |
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| FASTA Sequence |
Download |
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| Gene Name | SYNGR3 |
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| Gene ID | 618415 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Binding of Tau to synaptic vesicles is mediated by the transmembrane vesicle protein Synaptogyrin-3 during exocytosis |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 2 disordered segments; (1-10), (191-229) |
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| DisProt Annotation | |
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| TM Helix Prediction | 4TMHs; (26-44), (70-88), (109-127) & (146-168) |
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| Additional Comments | Several neurodegenerative diseases are associated with dysfunction of Synaptogyrin-3. Fly and mouse models of Tauopathy, reduction of Synaptogyrin-3 prevents the association of presynaptic Tau with vesicles, alleviates Tau-induced defects in vesicle mobility, and restores neurotransmitter release. |
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| Bibliography | McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P. Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. 2018 Feb 21;97(4):823-835.e8. doi: 10.1016/j.neuron.2018.01.022. Epub 2018 Feb 1. PMID: 29398363. |
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