Primary Information |
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| BoMiProt ID | Bomi9629 |
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| Protein Name | Synaptic vesicular amine transporter/Monoamine transporter/Solute carrier family 18 member 2/Vesicular amine transporter 2/VAT2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q27963 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_777078.1 |
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| Aminoacid Length | 517 |
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| Molecular Weight | 55756 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC18A2/VMAT2 |
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| Gene ID | 282471 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. |
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| PTMs | Glycosylation, Phosphorylation, and Disulphide bond |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q27963|VMAT2_BOVIN Synaptic vesicular amine transporter OS=Bos taurus OX=9913 GN=SLC18A2 PE=1 SV=1
MALSELALLRRLQESRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIEHEKDALEI
QTAKPGLTASAPGSFQNIFSYYDN*84STMVTGN*91STDHLQGALVHEATTQHMATN*112SSSASSDC
PSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFTGFCIMFISTVMFA
FSRTYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPP
FGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLRDPYILIA
AGSICFANMGIAMLEPALPIWMMETMCSHKWQLGVAFLPASVSYLIGTNVFGILAHKMGR
WLCALLGMIIVGMSILCIPLAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSV
YGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKE
EKMAILMDHNCPIKTKMYTQNSSQSHPIGEDEES*514ES*516D |
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| Predicted Disorder Regions | 61-75, 92-119, 498-517 |
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| DisProt Annotation | |
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| TM Helix Prediction | 10 TMHs; (21-43), (159-181), (224-246), (255-273), (296-314), (333-355), (362-380), (395-413), (420-438), (450-472) |
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| Significance of PTMs | VMAT2 undergoes phosphorylation by casein kinase II (CKII) on serines 512 and 514.Phosphorylation appears to regulate VMAT2 trafficking |
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| Bibliography | 1.Yao J, Erickson JD, Hersh LB. Protein kinase A affects trafficking of the vesicular monoamine transporters in PC12 cells. Traffic. 2004 Dec;5(12):1006-16. doi: 10.1111/j.1600-0854.2004.00240.x. PMID: 15522101. 2.Howell, M., Shirvan, A., Stern-Bach, Y., Steiner-Mordoch, S., Strasser, J. E., Dean, G. E., & Schuldiner, S. (1994). Cloning and functional expression of a tetrabenazine sensitive vesicular monoamine transporter from bovine chromaffin granules. FEBS letters, 338(1), 16–22. https://doi.org/10.1016/0014-5793(94)80108-8 |
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