Primary Information |
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| BoMiProt ID | Bomi9628 |
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| Protein Name | Synaptic vesicle glycoprotein 2A/p87 |
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| Organism | Bos taurus |
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| Uniprot ID | Q29397 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776387.1 |
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| Aminoacid Length | 742 |
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| Molecular Weight | 82589 |
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| FASTA Sequence |
Download |
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| Gene Name | SV2A |
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| Gene ID | 280936 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | vesicular neurotransmitter transporters.a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. |
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| Biochemical Properties | 12 transmembrane domains, with cytosolic N- and C-termini. |
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| PTMs | phosphorylation on Ser and Thr.N glycosylation on Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q29397|SV2A_BOVIN Synaptic vesicle glycoprotein 2A OS=Bos taurus OX=9913 GN=SV2A PE=2 SV=1
MEEGFRDRAAFIRGAKDIAKEVKKHATKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA
PADGYYRGEGAQDEEEGGAS*80S*81DAT*84EGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA
GVRGGLGDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG
VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS
VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW
MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF
FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFS*393VTHIKTIHQEDELIEIQSDTGAWYQRW
GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY*480
AARTKVFPGERVEHVTFN*498FTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT
SSNTFFRN*548CTFINTVFYNTDLFEYKFVNSRLVN*573STFLHNKEGCPLDVTGTGEGAYMVYFV
SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG
VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS
AALALGSSLALKLPETRGQVLQ |
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| Predicted Disorder Regions | (3-151) |
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| DisProt Annotation | |
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| TM Helix Prediction | 12TMHs; (168-190), (205-223), (236-254), (258-280), (293-315), (330-352), (446-468), (596-618), ( 625-647), (651-669), (687-709),& (713-731) |
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| Significance of PTMs | glycosylation of luminal asparagine residues increases their size to ∼95 kDa for lightly glycosylated and ∼250 kDa for heavily glycosylated SV2 proteins. |
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| Bibliography | Stout KA, Dunn AR, Hoffman C, Miller GW. The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance. ACS Chem Neurosci. 2019 Sep 18;10(9):3927-3938. doi: 10.1021/acschemneuro.9b00351. Epub 2019 Aug 23. PMID: 31394034. |
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