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Primary Information | |
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| BoMiProt ID | Bomi9625 |
| Protein Name | Synapsin-1 |
| Organism | Bos taurus |
| Uniprot ID | P17599 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776616.1 |
| Aminoacid Length | 706 |
| Molecular Weight | 74518 |
| FASTA Sequence | Download |
| Gene Name | SYN1 |
| Gene ID | 281510 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | abundant in the epithelial cells of neural tissues |
| Protein Function | nerve terminal phosphoprotein whose role is to encompass the linking of small synaptic vesicles to the cytoskeleton.join small synaptic vesicles to neuronal spectrin, microfilaments and microtubules; it can also bundle microtubules and microfilaments. |
| Biochemical Properties | has independent tubulin binding sites in the N-terminal head domain and in the C-terminal tail domain |
| Significance in milk | neurogenesis |
| PTMs | Glycosylation, Methylation, Phosphorylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P17599|SYN1_BOVIN Synapsin-1 OS=Bos taurus OX=9913 GN=SYN1 PE=1 SV=2 MNYLRRRLS*9DSNFMANLPNGYMTDLQRPQPPPPPPAAPS*39PGATTGPATATAERAS*55SAAPV AS*62PAAPS*67PGSSGGGGFFSSLSNAVKQT*87TAAAAATFS*96EQVGGGS*103GGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKP DFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSINSLHSVYNFCDKPWVFAQMVRLHKKLG TEEFPLINQTFYPNHKEMLSS*261TTYPVVVKMGHAHSGMGKVKVDNQHDFQDIASVVALTKT YATTEPFIDAKY*312DVRIQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTC SEIFGGLDICAVEALHGKDGRDHIIQVVGSSMPLIGDHQDEDKQLIVELVVNKMAQALPR QRQRDAS*427PGRGS*432HS*434QT*436PS*438PGALPLGRQISQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPTPQGQQHLSGLGPPAGSPLPQRLPSPTSVPQQPASQATPMT*526QGQGRQSRPVAGGP GAPPATRPPAS*551PS*553PQRQAGPPQAT*564RQTS*568VSGQAPPKAS*578GVPPGGQQRQGPPQKPPGPAGPTRQAS*605QAGPMPRTGPPTTQQPRPSGPGPAGRPTKPQLAQKPSQDVPPPATAAAGGPPHPQ LNKS*664QS*666LTNAFNLPEPAPPRPSLS*684QDEVKAETIRSLRKSFASLFSD |
| SCOP | Class : Alpha and beta proteins (a+b) Fold : ATP-grasp platform-like Superfamily : Glutathione synthetase ATP-binding domain-like Family : Synapsin C-terminal domain Domain Name : 1AUV A:214-417 Class : Alpha and beta proteins (a+b) Fold : PreATP-grasp domain Superfamily : PreATP-grasp domain Family : Synapsin domain Domain Name : 1AUV A:112-213 |
| CATH | Matched CATH superfamily 3.30.1490.20 3.30.470.20 3.40.50.20 |
| Predicted Disorder Regions | 42-45, 62-73, 461-472, 543-546, 700-706 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| Significance of PTMs | Phosphorylation of serine residue at 605 of the synapsin-1 peptide, 603QASQAGPGPR612 which is expected to regulate synaptic vesicle trafficking through a reciprocal process between phosphorylation and dephosphorylation of specific synapsin-1 sites. serine residue- 605 is reported to be a potential reciprocal site involved in regulating hippocampal synaptic plasticity.This site is also for O-GlcNAcylation,which is catalyzed by coordinated actions of O-GlcNAc transferase and O-GlcNAc amidase.Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles. |
| PDB ID | 1AUV,1AUX, |
| Bibliography | 1.Kang, M., Kim, C., Jeong, H. et al. Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes. Exp Mol Med 45, e29 (2013). https://doi.org/10.1038/emm.2013.56 2. |