Primary Information
BoMiProt ID	Bomi9622
Protein Name	Switch-associated protein 70
Organism	Bos taurus
Uniprot ID	P0C1G6
Milk Fraction	Exosomes
Aminoacid Length	585
Molecular Weight	68921
FASTA Sequence	Download
Gene Name	SWAP70
Protein Existence Status	Reviewed
Secondary Information
Protein Function	SWAP-70, a phosphatidylinositol 3,4,5-trisphosphate-interacting, F-actin-binding protein, participates in actin rearrangements.It is also a guanine nucleotide exchange factor that participates in the regulation of many cellular processes.SWAP70 is a protective molecule that can suppress the progression of NAFLD by inhibiting hepatic steatosis and inflammation. SWAP70 may be important for mitigating the progression of NAFLD.
Biochemical Properties	SWAP-70's structure consists of an N-terminal putative EF-hand domain, a pleckstrin homology domain that binds phosphatidylinositol 3,4,5-trisphosphate and is responsible for membrane localization, a tri-partite coiled-coil region, and a C-terminal F-actin-binding site, through which SWAP-70 specifically binds nonmuscle but not muscle actin.
PTMs	Phosphorylation at Tyr
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	24-31, 60-62, 579-585
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	Overexpression of SWAP70 in hepatocytes suppressed lipid deposition and inflammation
Bibliography	1.Qian Q, Li Y, Fu J, Leng D, Dong Z, Shi J, Shi H, Cao D, Cheng X, Hu Y, Luo Q, Hu M, Ran Y, Tang H, Liu H, Liu J. Switch-associated protein 70 protects against nonalcoholic fatty liver disease via suppression of TAK1. Hepatology. 2021 Oct 24. doi: 10.1002/hep.32213. Epub ahead of print. PMID: 34689362. 2.Ihara S., Oka T., Fukui Y. (2006) Direct binding of SWAP-70 to nonmuscle actin is required for membrane ruffling. J. Cell Sci. 119, 500–507. 3.Wakamatsu I., Ihara S., Fukui Y. (2006) Mutational analysis on the function of the SWAP-70 PH domain. Mol. Cell. Biochem. 293, 137–145. 4.