Primary Information |
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| BoMiProt ID | Bomi9616 |
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| Protein Name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1/BRG1-associated factor 47(BAF47) |
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| Organism | Bos taurus |
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| Uniprot ID | Q5BIN2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001035647.1 |
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| Aminoacid Length | 385 |
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| Molecular Weight | 44111 |
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| FASTA Sequence |
Download |
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| Gene Name | SMARCB1/BAF47 |
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| Gene ID | 537412 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | SMARCB1/INI1 is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex, and is identified as a potent and bona fide tumor suppressor. |
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| Biochemical Properties | Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. |
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| PTMs | Isopeptide bond formation,Phosphorylation at Ser,Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q5BIN2|SNF5_BOVIN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Bos taurus OX=9913 GN=SMARCB1 PE=2 SV=1
MMMMALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEER
KKIVASSHGKKTKPNAKDHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYL
REQKAKRNS*129QWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENA
SQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASA
IRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSE
LGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAE
MEKKIRDQDRNTRRMRRLANTAPAW |
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| Predicted Disorder Regions | 1-5, 62-80, 107-138, 364-369, 376-384 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Aberrant expression of SMARCB1/INI1 has been found in various tumors such as epithelioid sarcomas, schwannomatosis, synovial sarcomas. |
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| Bibliography | 1.Kohashi K, Oda Y. Oncogenic roles of SMARCB1/INI1 and its deficient tumors. Cancer Sci. 2017 Apr;108(4):547-552. doi: 10.1111/cas.13173. Epub 2017 Apr 12. PMID: 28109176; PMCID: PMC5406539. 2. |
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