Primary Information |
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| BoMiProt ID | Bomi9603 |
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| Protein Name | Suprabasin |
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| Organism | Bos taurus |
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| Uniprot ID | A6QQF6 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001098467.1 |
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| Aminoacid Length | 557 |
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| Molecular Weight | 56854 |
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| FASTA Sequence |
Download |
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| Gene Name | SBSN |
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| Gene ID | 540452 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | plays a role in the process of epidermal differentiation.SBSN may play a role in human tumourigenesis. |
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| Biochemical Properties | Three SBSN isoforms code for the secreted proteins with putative function as signalling molecules.The open reading frame codes for a small protein rich in glycine, with short tandem repeats in the central region. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 25-372, 399-408, 423-453, 464-529 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | protein kinase C phosphorylation sites are present in COOH.Also revealed 2 casein kinase II phosphorylation sites and 73 potentialN-myristoylation sites. |
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| Bibliography | 1.Park GT, Lim SE, Jang SI, Morasso MI. Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor. J Biol Chem. 2002 Nov 22;277(47):45195-202. doi: 10.1074/jbc.M205380200. Epub 2002 Sep 12. PMID: 12228223; PMCID: PMC1283087. 2.Pribyl, M., Hodny, Z., & Kubikova, I. (2021). Suprabasin-A Review. Genes, 12(1), 108. https://doi.org/10.3390/genes12010108 |
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