Primary Information |
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| BoMiProt ID | Bomi9597 |
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| Protein Name | Suppressor of tumorigenicity 7 protein-like |
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| Organism | Bos taurus |
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| Uniprot ID | A3KN28 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001076950.1 |
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| Aminoacid Length | 555 |
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| Molecular Weight | 62636 |
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| FASTA Sequence |
Download |
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| Gene Name | ST7L |
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| Gene ID | 534657 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Tumour supressor protein.found to decrease glycogen synthase kinase (GSK)-3β phosphorylation and downregulate active β-catenin protein expression, thereby leading to repression of β-catenin transcriptional activity. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 9-15, 126-147, 272-280 |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (38-60) and (80-102) |
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| Bibliography | Wang H, Sun L, Jiang J, Yu S, Zhou Q. Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3β/β-catenin signalling. Clin Exp Pharmacol Physiol. 2020 Jan;47(1):119-126. doi: 10.1111/1440-1681.13166. Epub 2019 Sep 9. PMID: 31429477. |
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