Primary Information |
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| BoMiProt ID | Bomi9596 |
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| Protein Name | Suppressor of tumorigenicity 14 protein homolog/Serine protease 14 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0IIH7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070006.1 |
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| Aminoacid Length | 855 |
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| Molecular Weight | 94964 |
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| FASTA Sequence |
Download |
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| Gene Name | ST14/PRSS14 |
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| Gene ID | 767617 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | ST14/Prss14 is an emerging therapeutic target for breast cancer where HER2 is not applicable.It also plays an important role in transendothelial migration of epithelial cancer cells and activated macrophage . |
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| Biochemical Properties | The N terminal fragment containing cytoplasmic, transmembrane domains, and a short ectodomain is linked to the rest of the C-terminal fragment containing CUB, LDLR, and a protease domain. Protease activity of ST14/Prss14 requires cleavage at Arg 614, presumably by autocatalysis |
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| PTMs | N-Linked Glycosylation at Asn,Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0IIH7|ST14_BOVIN Suppressor of tumorigenicity 14 protein homolog OS=Bos taurus OX=9913 GN=ST14 PE=2 SV=1
MKSERARRGAGGS*13GDLGAGFKYTSRPENMNGCEEGVEFLPANNSSKVEKGGPRRWVVLMA
VLAAFLALSLLAGLLAWHFQDRNVRVQKIFNGYLSVRNENFLDAYENSN*109STEFANLAKKV
KEALKFLYSGIPVLGPYHKTSTVTAFSEGSVIAYYWSEFDIPKHLVKEAEQAMAEKRMVT
VPPRARSMSSFVMTSVVAFPSDPRIIQNTQDNSCSFALHAQGSEPIRFSTPGFPDSPYPS
HARCQWTLRGDADSVLSLTFRSFDVATCDERGSDLVTVYDTLSPVEPRAVVQLCGTYPPS
YN*302LTFLSSQNVLLITLVTSTERRHPGFEAVFFQLPRMSSCGGYLRAAQGTFNSPYYPGHY
PPNIN*365CTWHIEVPDNKNVKVRFKAFFLQEPNVPVGSCTKDYVEINGEKYCGERPQFVASS
RNNKITVHFHSDQSYTDTGFLAEFLSFDARDPCPGSFMCNTGRCIRKELRCDGWADCTDY
SDELDCKCN*489ATYQFTCRDKFCKPLFWVCDSVKDCEDGSDEEGCSCPPNTFKCGNGKCLPQ
SQQCDRKDDCGDGSDEAKCQDGKAVPCTEHTHRCLNGLCVDKSNPQCDGNEDCTDGSDEK
DCDCGRRSFTRQSRVVGGENSDQGEWPWQVSLHAQGHGHLCGASLISPSWMISAAHCFVD
DRGFRYSEHSVWTAFLGLHDQSKRNAPGVQERGLQRIIKHPFFNDFTFDYDIALLQLDRP
VEYSATIRPICLPAADYTFPTGKAIWVTGWGHTQEAGQGAMILQKGEIRVIN*772QTTCEHLL
PQQITPRMICVGYLSGGVDACQGDSGGPLSSPEEDGRMFQAGVVSWGEGCAQRNKPGVYT
RLPVFRDWIKAQIGV |
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| Predicted Disorder Regions | (1-21) |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (55-77) |
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| Additional Comments | ST14/Prss14 can initiate tumorigenesis by causing tumor-associated inflammation. |
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| Bibliography | 1.Kim S, Yang JW, Kim C, Kim MG. Impact of suppression of tumorigenicity 14 (ST14)/serine protease 14 (Prss14) expression analysis on the prognosis and management of estrogen receptor negative breast cancer. Oncotarget. 2016 Jun 7;7(23):34643-63. doi: 10.18632/oncotarget.9155. PMID: 27167193; PMCID: PMC5085182. 2.Kim C, Lee HS, Lee D, Lee SD, Cho E-G, Yang SJ,
Kim SB, Park D, Kim MG. Epithin/PRSS14 proteolytically
regulates angiopoietin receptor Tie2 during transendothelial
migration. Blood. 2011; 117:1415–1424. 3.Lee D, Lee HS, Yang SJ, Jeong H, Kim D-Y, Lee SD,
Oh JW, Park D, Kim MG. PRSS14/Epithin is induced
in macrophages by the IFN-γ/JAK/STAT pathway and
mediates transendothelial migration. Biochem Biophys Res
Commun. 2011; 405:644–650. |
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