Primary Information |
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| BoMiProt ID | Bomi9593 |
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| Protein Name | Superoxide dismutase [Mn], mitochondrial |
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| Organism | Bos taurus |
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| Uniprot ID | P41976 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_963285.2 |
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| Aminoacid Length | 222 |
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| Molecular Weight | 24638 |
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| FASTA Sequence |
Download |
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| Gene Name | SOD2 |
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| Gene ID | 281496 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | mitochondrial superoxide dismutase (SOD2) is a major system converting diffusion-restricted superoxide radicals derived from the electron transport chain into highly diffusible hydrogen peroxide (H2O2). |
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| PTMs | N6-acetylation at Lys,3'-nitration at Tyr, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Nitration coupled with oxidation inhibits the catalytic activity.Acetylation at Lys-122 decreases enzymatic activity.Polyubiquitinated; leading to proteasomal degradation. |
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| Linking IDs | |
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| Bibliography | 1.Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG. Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch. Antioxid Redox Signal. 2020 Apr 1;32(10):701-714. doi: 10.1089/ars.2019.7962. PMID: 31968997; PMCID: PMC7047081. |
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