Search by BoMiProt ID - Bomi9535

Primary Information

BoMiProt ID Bomi9535
Protein Name Store-operated calcium entry-associated regulatory factor/SOCE-associated regulatory factor/Transmembrane protein 66/SARAF
Organism Bos taurus
Uniprot IDQ08E24
Milk FractionWhey
Ref Sequence ID NP_001070324.1
Aminoacid Length 335
Molecular Weight 36314
FASTA Sequence Download
Gene Name SARAF/TMEM66
Gene ID 515461
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells SARAF inhibits SOAR only when Ca2+ levels are elevated .Negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 200-258, 285-335
DisProt Annotation
TM Helix Prediction 3TMHs; (4-26), (172-194), (256-274)
Bibliography Dagan I, Palty R. Regulation of Store-Operated Ca2+ Entry by SARAF. Cells. 2021 Jul 26;10(8):1887. doi: 10.3390/cells10081887. PMID: 34440656; PMCID: PMC8391525.