Primary Information |
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| BoMiProt ID | Bomi9535 |
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| Protein Name | Store-operated calcium entry-associated regulatory factor/SOCE-associated regulatory factor/Transmembrane protein 66/SARAF |
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| Organism | Bos taurus |
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| Uniprot ID | Q08E24 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070324.1 |
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| Aminoacid Length | 335 |
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| Molecular Weight | 36314 |
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| FASTA Sequence |
Download |
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| Gene Name | SARAF/TMEM66 |
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| Gene ID | 515461 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | SARAF inhibits SOAR only when Ca2+ levels are elevated .Negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 200-258, 285-335 |
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| DisProt Annotation | |
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| TM Helix Prediction | 3TMHs; (4-26), (172-194), (256-274) |
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| Bibliography | Dagan I, Palty R. Regulation of Store-Operated Ca2+ Entry by SARAF. Cells. 2021 Jul 26;10(8):1887. doi: 10.3390/cells10081887. PMID: 34440656; PMCID: PMC8391525. |
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