Search by BoMiProt ID - Bomi9533


Primary Information

BoMiProt ID Bomi9533
Protein Name Stomatin-like protein 2, mitochondrial/SLP-2
Organism Bos taurus
Uniprot IDQ32LL2
Milk FractionWhey,Casein
Ref Sequence ID NP_001033157.1
Aminoacid Length 356
Molecular Weight 38733
FASTA Sequence Download
Gene Name STOML2
Gene ID 510324
Protein Existence Status reviewed

Secondary Information

Protein Function an inner mitochondrial membrane protein,a regulator of mitochondrial biogenesis and ATP production.STOML2 activated MEK/ERK signaling and suppressed mitochondrial apoptosis pathway in HeLa cervical cancer cells, through altering the ability of mitochondria to buffer Ca2+ and shape cytosolic Ca2+ signaling.
Significance in milk phosphorylation on Ser and Tyr.Acetylation on Lys
PTMs Acetylation, Lipidation, Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q32LL2|STML2_BOVIN Stomatin-like protein 2, mitochondrial OS=Bos taurus OX=9913 GN=STOML2 PE=2 SV=1 MLARAARGTGALLLKGS*17VQASARAPRRASSGLPRNTVVLFVPQQEAWVVERMGRFHRILE PGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVE DPEY*124AVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDI HVPPRVKESMKMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQA AGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPS NPGDVTSMVAQAMGVYGALTKAPIPEAQDS*330VSSRSSRDVRSTDASLDEELDRVKLS
Predicted Disorder Regions 1-10, 18-29, 318-356
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Ma, W., Chen, Y., Xiong, W. et al. STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation. J Exp Clin Cancer Res 40, 359 (2021). https://doi.org/10.1186/s13046-021-02116-0. 2.Zhang H, Wu G, Feng J, Lu X, Liu P. Expression of STOML2 promotes proliferation and glycolysis of multiple myeloma cells via upregulating PAI-1. J Orthop Surg Res. 2021 Nov 13;16(1):667. doi: 10.1186/s13018-021-02819-2. PMID: 34774067; PMCID: PMC8590323.