Primary Information |
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| BoMiProt ID | Bomi9446 |
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| Protein Name | Spermatogenesis-associated protein 6 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJG1 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 487 |
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| Molecular Weight | 56137 |
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| FASTA Sequence |
Download |
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| Gene Name | SPATA6 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | involved in myosin-based microfilament transport through interaction with myosin subunits (e.g., MYL6). |
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| Biochemical Properties | 488 amino acids long,bins to MYL6 |
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| PTMs | Glycosylation, Isopeptide bond formation, Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJG1|SPAT6_BOVIN Spermatogenesis-associated protein 6 OS=Bos taurus OX=9913 GN=SPATA6 PE=2 SV=2
MPKVKALQCALALEIRSVTCPGVVLKDKEDIYLSICVFGQYKKTQCVPANFPLVFNARMV
FEKVFPEAVDPGDVVAQLEYDTALFELIQLVPPVGETLSTYDENTRDFMFPGPNQISGHH
DSNRQVTMRRISGLRGIAPKLEFSTTSVITECLISSRKCRTQDKFVYHTAPVEKPHSRLQ
N*181RTSRSQKKKSKSPERNKYCINAKNYEQPTTSKSHS*216PS*218PYTKRRMCELSEDTRRRLAHLN
LGPYEFKKETDKPPFVIRHVDPPS*264PRADALFGS*273PGRDCERDGWSRLHNDHSHLGCYRPKD
YKVIRTPHGRDFDESLERCEDYLS*324SRSCSKPQHSARTLLVHS*342APS*345TMPKHSPS*353PVLNRASLRERFHSDWCSPSNCDEIHDRVKNVLKSHQAHQRHLYDERDPEKEDELELKRGLLYRDSA
YDS*423DPEYSSFQRPRGTLHLDDGEYWSNRAASYKGKSHRPIFENS*464MDKIYRNLYKKACSSV
SHTQES*486F |
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| Predicted Disorder Regions | 111-119, 179-219, 252-267, 328-358, 399-405, 423-430, |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Inactivation of SPATA6 leads to male infertility and teratospermia.down-regulation of SPATA6 can induce apoptosis . |
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| Bibliography | 1.Huo S, Du W, Shi P, Si Y, Zhao S. The role of spermatogenesis-associated protein 6 in testicular germ cell tumors. Int J Clin Exp Pathol. 2015 Aug 1;8(8):9119-25. PMID: 26464655; PMCID: PMC4583887. 2.Yuan S, Stratton CJ, Bao J, Zheng H, Bhetwal BP, Yanagimachi R, Yan W. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E430-9. doi: 10.1073/pnas.1424648112. Epub 2015 Jan 20. PMID: 25605924; PMCID: PMC4321249. |
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