Primary Information |
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| BoMiProt ID | Bomi9411 |
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| Protein Name | Sorting nexin-8 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KHV6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039998.1 |
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| Aminoacid Length | 459 |
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| Molecular Weight | 51619 |
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| FASTA Sequence |
Download |
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| Gene Name | SNX8 |
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| Gene ID | 614344 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Sorting nexins anchor trafficking machines to membranes by binding phospholipids. intracellular trafficking.protein transport from early endosomes to the trans-Golgi network . |
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| Biochemical Properties | a distinct phosphoinositide (PI)-binding domain, the SNX-PX domain which preferentially targets these proteins to phosphatidylinositol-3-phosphate (PI(3)P) on endosomes. also contain a BAR (Bin/amphiphysin/Rvs) domain, which can sense, stabilize and induce membrane curvature. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-61, 334-349, 446-458 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Dyve AB, Bergan J, Utskarpen A, Sandvig K. Sorting nexin 8 regulates endosome-to-Golgi transport. Biochem Biophys Res Commun. 2009 Dec 4;390(1):109-14. doi: 10.1016/j.bbrc.2009.09.076. Epub 2009 Sep 24. PMID: 19782049. |
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