Search by BoMiProt ID - Bomi9411

Primary Information

BoMiProt ID Bomi9411
Protein Name Sorting nexin-8
Organism Bos taurus
Uniprot IDQ2KHV6
Milk FractionWhey
Ref Sequence ID NP_001039998.1
Aminoacid Length 459
Molecular Weight 51619
FASTA Sequence Download
Gene Name SNX8
Gene ID 614344
Protein Existence Status reviewed

Secondary Information

Protein Function Sorting nexins anchor trafficking machines to membranes by binding phospholipids. intracellular trafficking.protein transport from early endosomes to the trans-Golgi network .
Biochemical Properties a distinct phosphoinositide (PI)-binding domain, the SNX-PX domain which preferentially targets these proteins to phosphatidylinositol-3-phosphate (PI(3)P) on endosomes. also contain a BAR (Bin/amphiphysin/Rvs) domain, which can sense, stabilize and induce membrane curvature.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-61, 334-349, 446-458
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Dyve AB, Bergan J, Utskarpen A, Sandvig K. Sorting nexin 8 regulates endosome-to-Golgi transport. Biochem Biophys Res Commun. 2009 Dec 4;390(1):109-14. doi: 10.1016/j.bbrc.2009.09.076. Epub 2009 Sep 24. PMID: 19782049.