Primary Information |
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| BoMiProt ID | Bomi9410 |
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| Protein Name | Sorting nexin-29 |
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| Organism | Bos taurus |
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| Uniprot ID | Q08DX0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001070330.1 |
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| Aminoacid Length | 817 |
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| Molecular Weight | 91337 |
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| FASTA Sequence |
Download |
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| Gene Name | SNX29 |
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| Gene ID | 518366 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | SNX29 was involved in the regulation of a number of biological processes, such as TGF-beta, ErbB, and Wnt signalling pathway.SNX29 gene played a significant role in the development of schizophrenia (SCZ), bipolar disorder (BPD) or major depressive disorder (MDD) disorders in the Han Chinese population. |
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| Biochemical Properties | enable phosphatidylinositol binding activity |
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| Significance in milk | associated with body size and weight. |
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| PTMs | Phosphorylation at Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q08DX0|SNX29_BOVIN Sorting nexin-29 OS=Bos taurus OX=9913 GN=SNX29 PE=2 SV=1
MSGTQNNDMKRQFLLERLLDAVKQCQIRFGGRKEIASDSDSRVTCLCAQFEAVLQHGLKR
SRGLALTAAAIKQAAGFASKTETEPVFWFYVKEVLSKHELQRFHALRHIASDVGRGRAWL
RCALNENSLERYLHMLLADRGRLSTFYEDWAFVMDEERSSMLPTMAAGLNSILFAINIDN
KDLNGQSKFAPTVSDLLKESTQNVTSLLKESTQGVSSLFREITASSAVSILSRAEQETDP
LPVVSKHVSADAKCKRERKKKKKVTNIIS*269FDDEEDEQSSGDVFKKIPGAGES*292S*293EENSDRS
SINIMSAFESPFGPNSNGSQGSNSWKIDSLS*331LNGEFGYQKLDVKS*345IDDEDADENEDDVCG
SMPGRKRPGHSESPEKPLDAGTCLSQMHGWAPLQVLHGHAEVLFPVSGVGSYGPADAPLG
SLENGTGPEDHILPEPGPRYSVEASPPGQES*451PLSSLLPSASVPESMTVSDLRQAIVAMMN
RKDELEEENRSLRNLLDGEMEHSAALRQEVDTLKRKVAEQEERHVTKVQALARENEVLKV
QLKKYVGAVQMLKREGQTAEVVPNLWNIDGEVTVPEQKPGEVAEELTSSYERKLIEVAEM
HGELIEFNERLHRALVAKEALVSQMRQELIDLRGPVPGDLS*641QT*643S*644EDQS*648LSDFEISNRALINVWIPSVFLRGKAANAFHVYQVYIRIKDDEWNVYRRYAEFRTLHHKLQNKYPQVRAFNFP
PKKAIGNKDAKFVEERRKQLQTYLRSVMNKVIQAVPEFTASPQKETLTQLMPFFVDITPP
GDALTKNSRPKVASRFPKLARGHPRETRNVEPQSGDL |
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| Predicted Disorder Regions | 247-330, 350-356, 435-459 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Leads to genetic instability causing mental disorders |
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| Bibliography | 1.Chen JH, Zhao Y, Khan RAW, Li ZQ, Zhou J, Shen JW, Xiang SY, Li NN, Wen ZJ, Jian XM, Song ZJ, Stewart R, Wang Z, Pan D, He L, Xu YF, Shi YY. SNX29, a new susceptibility gene shared with major mental disorders in Han Chinese population. World J Biol Psychiatry. 2021 Sep;22(7):526-534. doi: 10.1080/15622975.2020.1845793. Epub 2020 Dec 8. PMID: 33143498. |
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