Primary Information |
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| BoMiProt ID | Bomi9316 |
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| Protein Name | Solute carrier family 22 member 17/24p3 receptor/Lipocalin-2 receptor |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SZQ2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001124227.1 |
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| Aminoacid Length | 567 |
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| Molecular Weight | 60174 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC22A17 |
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| Gene ID | 539848 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. |
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| Significance in milk | involved in inflammatory conditions caused by bacteria |
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| PTMs | Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3SZQ2|S22AH_BOVIN Solute carrier family 22 member 17 OS=Bos taurus OX=9913 GN=SLC22A17 PE=2 SV=1
MGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGLASDPIFTLAPPL
HCHYGAFPPN*70ASGWEQPPN*79ASGVSVASAALAASAASRLATSTDPSCSGFAPPDFNHCLKD
WDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLL
TLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGE
LVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQ
SVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGF
TNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMT
LTGIASLALLGLWDYLNEAAITTFSVLGLFSSQAAGILSTLLAAEVIPTTVRGRGLGLIM
ALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELC
RRPSLLQQPPPNRCDHVPLLATPNPAL |
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| Predicted Disorder Regions | (71-80), (315-320), (542-567) |
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| DisProt Annotation | |
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| TM Helix Prediction | 11TMHs ; (147-169), (176-194), (200-222), (235-257), (266-284), (351 -369), (384- 406), (413-431), (440-462), (473-491) & (500-522) |
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| Bibliography | Wei, J., Gao, X., Qin, Y., Liu, T., & Kang, Y. (2020). An Iron Metabolism-Related SLC22A17 for the Prognostic Value of Gastric Cancer. OncoTargets and therapy, 13, 12763–12775. https://doi.org/10.2147/OTT.S287811 |
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