Primary Information |
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BoMiProt ID | Bomi9312 |
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Protein Name | Solute carrier family 2, facilitated glucose transporter member 3/Glucose transporter type 3, brain |
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Organism | Bos taurus |
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Uniprot ID | P58352 |
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Milk Fraction | Exosomes,MFGM |
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Aminoacid Length | 494 |
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Molecular Weight | 54020 |
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FASTA Sequence |
Download |
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Gene Name | SLC2A3 |
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Protein Existence Status | Reviewed |
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Secondary Information |
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Protein Function | The glucose transporter 3 (GLUT3) is a high-affinity glucose transporter that is highly expressed in mammalian neurons.GLUT3 is also important for breast cancer cell survival and adaptation in the brain microenvironment and whether GLUT3 mediates cancer metabolic reprogramming. |
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PTMs | Phosphorylation at Ser/Thr,N-linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P58352|GTR3_BOVIN Solute carrier family 2, facilitated glucose transporter member 3 OS=Bos taurus OX=9913 GN=SLC2A3 PE=2 SV=1
MGTTKVTAPLIFAISVATIGSFQFGYNTGVINAPEAIIKDFLN*43YTLEERSEPPPSSVLLT
SLWSLSVAIFSVGGMIGSFSVGLFVNRFGRGNSMLIVNLLAIAGGCLMGFCKIAESVEML
ILGRLIIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLKVILGT
EDLWPLLLGFTILPAIIQCAALPFCPESPRFLLINRKEEEKAKEILQRLWGT*232EDVAQDIQ
EMKDESMRMSQEKQVTVLELFRAPNYRQPIIISIMLQLSQQLSGINAVFYYSTGIFKDAG
VQEPVYATIGAGVVNTIFTVVSVFLVERAGRRTLHLIGLGGMAFCSILMTISLLLKDN*358YS
WMSFICIGAILVFVAFFEIGPGPIPWFIVAELFGQGPRPAAMAVAGCSNWTSNFLVGLLF
PSAAFYLGAYVFIVFTVFLVIFWVFTFFKVPETRGRTFEEITRAFEGQTQTGTRGEKGPI
MEMNS*585IQPTKDT*592NA |
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Predicted Disorder Regions | 243-247, 467-494 |
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DisProt Annotation | |
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TM Helix Prediction | 12 TMHs; (7-25),(62-84),(95-117),(121-143),(156-174),(183-205),(270-292),(304-326),(333-355),(359-377),(384-406),(425-447) |
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Additional Comments | GLUT3 is highly overexpressed in brain metastatic breast cancers and mediates glucose metabolic reprogramming. |
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Bibliography | 1.Kuo MH, Chang WW, Yeh BW, Chu YS, Lee YC, Lee HT. Glucose Transporter 3 is Essential for the Survival of Breast Cancer Cells in the Brain. Cells. 2019 Dec 4;8(12):1568. doi: 10.3390/cells8121568. PMID: 31817208; PMCID: PMC6952949. |