Primary Information |
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| BoMiProt ID | Bomi9274 |
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| Protein Name | Sodium/glucose cotransporter 5/Na(+)/glucose cotransporter 5/Solute carrier family 5 member 10 |
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| Organism | Bos taurus |
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| Uniprot ID | Q6R4Q5 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001001442.1 |
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| Aminoacid Length | 597 |
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| Molecular Weight | 64726 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC5A10/SGLT5 |
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| Gene ID | 407227 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Human SGLT-5 is exclusively expressed in the kidney and acts as a kidney mannose transporter. |
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| Biochemical Properties | Sodium glucose cotransporters (SGLT) actively catalyse carbohydrate transport across cellular membranes. Six of the 12 known SGLT family members have the capacity to bind and/or transport monosaccharides (SGLT-1 to 6) |
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| Significance in milk | Milk protein synthesis |
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| PTMs | N-Linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q6R4Q5|SC5AA_BOVIN Sodium/glucose cotransporter 5 OS=Bos taurus OX=9913 GN=SLC5A10 PE=2 SV=1
MAVDN*5STSDAHTPGRQLTVVDIAIIAVYFALNVAVGIWSSCRASRNTVRGYFLAGRDMTW
WPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWN*97ATYVLLALAWVFVPIYLSSEIVT
MPEYMQKRYGGQRIRMYLSVLSLLLSVFTKISIDLYAGALFVHICLGWNFYLSTVIMLAI
TALYTIAGGLTAVIYTDALQTLVMVAGAVILTIKAFEQIGGYEQLAEAYAQAVPSRTISN
TTCHVPRADAMHMFRDPYTADLPWTGMTFGLTIMAAWYWCTDQVIVQRSLSARDLNHAKG
GSILASYLKMLPMGLMVMPGMISRVLFPDDVGCVVPAECLRACGAEIGCSNIAYPKLVME
LMPTGLRGLMVAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPRAGERELLLVGRLVIVV
LVGVSVAWIPVLQGSNGGQLFIYMQSVTSSLAPPVTAVFVLGIFWRRANEQGAFWGLMAG
LAVGATRLVLEFLHPAPPCGHPDTRPPILHGVHYLHFAVALFLLSGAVVVAGSLLTPHPQ
GVQIQSLTWWTLAQDLPLGVKTGDGRASQRHAFWARVCGVNAILLMCVNIFFYTYFA |
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| Predicted Disorder Regions | (1-12) |
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| DisProt Annotation | |
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| TM Helix Prediction | 14TMHs; (19-41), (61-83), (98-116), (136-158), (173-195), (202-220), (262-280), (300-322), (368-390), (410-432), (447-465), (472-490), (514-536), (573-595) |
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| Additional Comments | Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study |
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| Bibliography | 1.Loomis SJ, Köttgen A, Li M, Tin A, Coresh J, Boerwinkle E, Gibbs R, Muzny D, Pankow J, Selvin E, Duggal P. Rare variants in SLC5A10 are associated with serum 1,5-anhydroglucitol (1,5-AG) in the Atherosclerosis Risk in Communities (ARIC) Study. Sci Rep. 2019 Apr 11;9(1):5941. doi: 10.1038/s41598-019-42202-0. PMID: 30976018; PMCID: PMC6459884. 2.Grempler R, Augustin R, Froehner S, Hildebrandt T, Simon E, Mark M, Eickelmann P. Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter. FEBS Lett. 2012 Feb 3;586(3):248-53. doi: 10.1016/j.febslet.2011.12.027. Epub 2011 Dec 30. PMID: 22212718. 3. |
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