It catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Also involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.
PTMs
N6-acetylation at Lysine
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions
NA
DisProt Annotation
TM Helix Prediction
No TM helices
Bibliography
1.Della Ragione F, Oliva A, Gragnaniello V, Russo GL, Palumbo R, Zappia V. Physicochemical and immunological studies on mammalian 5'-deoxy-5'-methylthioadenosine phosphorylase. J Biol Chem. 1990 Apr 15;265(11):6241-6. PMID: 2108157.