Primary Information |
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| BoMiProt ID | Bomi9247 |
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| Protein Name | Small nuclear ribonucleoprotein-associated protein N |
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| Organism | Bos taurus |
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| Uniprot ID | Q17QN3 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001073265.1 |
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| Aminoacid Length | 240 |
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| Molecular Weight | 24622 |
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| FASTA Sequence |
Download |
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| Gene Name | SNRPN |
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| Gene ID | 780877 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | involved in tissue-specific alternative RNA processing events |
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| PTMs | Methylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 6 disordered segments; (1-9), (57-61), (82-176), (182-186), (192-212), (224-240) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | SNRPN-methylation is used to detect uniparental disomy of chromosome 15.decreased levels of the maternal allele methylation in the SNRPN DMR has been observed in children conceived by assisted reproductive technologies (ART), suggesting that the SNRPN methylation pattern is affected by in vitro culture systems.DMR methylation levels are found to be diminished in embryonic tissues in abnormal pregnancy. |
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| Additional Comments | Artificial reproductive techniques, such as prolonged in vitro culture and SCNT, lead to abnormal reprogramming of imprinting of SNRPN gene by altering methylation levels at this locus. |
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| Bibliography | Suzuki, J., Therrien, J., Filion, F. et al. In vitroculture and somatic cell nuclear transfer affect imprinting of SNRPN gene in pre- and post-implantation stages of development in cattle. BMC Dev Biol 9, 9 (2009). https://doi.org/10.1186/1471-213X-9-9 |
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