Primary Information |
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| BoMiProt ID | Bomi9207 |
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| Protein Name | SLAIN motif-containing protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3MHV6 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001030482.1 |
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| Aminoacid Length | 582 |
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| Molecular Weight | 62770 |
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| FASTA Sequence |
Download |
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| Gene Name | SLAIN2 |
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| Gene ID | 534203 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase |
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| PTMs | Acetylation, Methylation and Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3MHV6|SLAI2_BOVIN SLAIN motif-containing protein 2 OS=Bos taurus OX=9913 GN=SLAIN2 PE=2 SV=1
MEDVNSDVNADQEVRKLQELVKMLEKQNEQLRSRSGAVQGAGS*43FGPGS*48PVRAGASTPSSG
TAS*63PRGFPLGLSAKSGSGAGSGPRRTS*88SEELRDATSLLAAGEGGLLDEVEPLRPEELERL
SGWEEEEESWLYSS*134PKKKLTPMQKSVS*147PLVWCRQVLDYPS*160PDVECAKKSLIHKLDQTMS*179ALKRQNLYNNPFNSVSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSS
SDRNPPLS*248PQS*251S*252IDS*255ELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATASRRSSGSSCNSTRRGTFS*316DQELDAQS*324LDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPR
NSPRSRSPARGIEYSRVS*378PQPMISRLQQPRLS*392LQGHPTDLQTTNVKNEEKLRRS*414LPNLSR
TSNTQVDSVKSSRS*434DSNFQVPNGGIPRMQPQASAIPS*457PGKFRS*463PAAPS*468PLALRQPVKAFSNHGSGSPGSQETTQLMQTTSSPGPPMVQNTVPANPPSNINSTTLTRPAGTTVMRSGLPRP
SAPSAGGIPVPRSKLAQPVRRSLPAPKTYGSMKDDSWKDGCY |
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| Predicted Disorder Regions | 17-33, 54-60, 75-82, 97-126, 138-145, 171-177, 188-209, 233-333, 499-502 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Significance of PTMs | The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5 |
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| Bibliography | van der Vaart, B., Manatschal, C., Grigoriev, I., Olieric, V., Gouveia, S. M., Bjelic, S., Demmers, J., Vorobjev, I., Hoogenraad, C. C., Steinmetz, M. O., & Akhmanova, A. (2011). SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. The Journal of cell biology, 193(6), 1083–1099. https://doi.org/10.1083/jcb.201012179 |
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